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Title

Blood lipid components and osteoarthritis risk: a stratified analysis from the NHANES

Abstract

This study aimed to explore the associations between total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels and the prevalence of OA, as well as the associations between these blood lipid components and OA among populations with different characteristics. Data from the National Health and Nutrition Examination Survey (NHANES) were used to investigate the correlations between various blood lipid components and OA. Further stratified analyses were conducted by gender, age, body mass index (BMI), and race to identify specific associations between blood lipid components and OA in different characteristic populations. Moreover, we studied the nonlinear associations among these associations and performed threshold and saturation effects analysis. In addition, we examined the correlation between dietary cholesterol intake and OA to explore the potential impact of dietary habits on OA. After adjusting for potential confounders, higher levels of TC, TG, and HDL were correlated with an increased prevalence of OA. Further stratified analyses revealed differences in the associations between blood lipid components and OA across different gender, age, race, and BMI groups. Moreover, in specific populations, including non-Hispanic whites, Mexican Americans, participants with a BMI ≥30 kg/m2, and those aged <60 years, there is a nonlinear association between TG or HDL levels and the prevalence of OA, with significant inflection points observed at certain levels. However, no significant correlation was found between dietary cholesterol intake and the prevalence of OA. In this study, we observed a close association between blood lipids and the prevalence of OA and found differences in the associations between various blood lipid components and the prevalence of OA in different populations. Managing blood lipid levels could be an important strategy for preventing and treating OA.

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Author Contributions Statement

XYT, BW designed the research protocol. XYT, BW, XKH, DFZ and DQ were involved in data collection and literature search. XYT, BW analyzed, interpreted and managed the data. XYT, QG drafted the manuscript. BW, CQ reviewed and revised the manuscript. BW, CQ supervised and managed the research activities. All authors read and approved the final manuscript.

• Health sciences > Biomarkers
• Health sciences > Risk factors

Open Access

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Competing Interests

No, I declare that the authors have no competing interests as defined by Nature Research, or other interests that might be perceived to influence the results and/or discussion reported in this paper.

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Third Party Material

All of the material is owned by the authors and/or no permissions are required.

Data Availability

Yes, I have research data to declare.

“The original data presented in the study are openly available in NHANES database at https://www.cdc.gov/nchs/nhanes/. Any additional data and the data supporting the plots within this paper are available from the corresponding author upon reasonable request.”

Acknowledgements

“We are grateful for the valuable contributions of all participants and staff involved in the National Health and Nutrition Examination Survey, as well as the National Center for Health Statistics.”