Dear Editor:
尊敬的编辑：

Enclosed with this letter is a manuscript entitled “Structural identification and anti-stomatitis activity of one arabinose- and galacturonic acid-rich polysaccharide from Rehmannia glutinosa” which we hope will be reviewed by Food Bioscience. We declare that it was an original work, and all the authors mutually agreed on submission to Food Bioscience, and it is not under consideration for publication elsewhere. All the authors declare that they have no conflict of interest.
随信附上一份题为“来自地黄的富含阿拉伯糖和半乳糖醛酸的多糖的结构鉴定和抗口炎活性”的手稿，我们希望Food Bioscience对此进行审查。我们声明这是一篇原创作品，所有作者都同意将其提交给 Food Bioscience，并且不考虑在其他地方发表。所有作者都声明他们没有利益冲突。

(i) What is new or novel about the paper
（i） 论文有什么新颖之处

In this study, the peptide B1 component with excellent gastric mucosal repair activity was isolated, purified, and identified using Corneum Galli Gigeri Endothelium (CGGE) as the raw material. It is mainly composed of new peptide segments such as DYPELS, LPPLEH, SFYYGK, DDDGVGF, VVLPR, and LPYPR. Among them, except for LPYPR, which has been reported to have activities such as lowering blood pressure and cholesterol, the other 5 peptide segments are newly discovered active peptides with the ability to repair gastric mucosal damage. Additionally, based on the GES-1 cell model, we further elucidated its mechanism of improving gastric mucosal damage. We found that the B1 component can regulate cytokines such as EGF and TGF-α by reducing oxidative stress, enhance the synthesis of HGF, TFF, and VEGF, modulate the protein expression of Cdc42, Rac1, and RhoA, associate with the Rho signaling pathway, promote cell migration and proliferation, and consequently facilitate gastric mucosal wound healing.
本研究以角膜内皮（Corneum Galli Gigeri Endothelium，CGGE）为原料，分离、纯化、鉴定具有优异胃黏膜修复活性的肽B1组分。它主要由DYPELS、LPPLEH、SFYYGK、DDDGVGF、VVLPR和LPYPR等新肽片段组成。其中，除了据报道具有降低血压和胆固醇等活性的LPYPR外，其他5个肽段都是新发现的具有修复胃粘膜损伤能力的活性肽。此外，基于GES-1细胞模型，我们进一步阐明了其改善胃粘膜损伤的机制。我们发现 B1 组分可以通过减少氧化应激来调节 EGF 和 TGF-α 等细胞因子，增强 HGF、TFF 和 VEGF 的合成，调节 Cdc42、Rac1 和 RhoA 的蛋白表达，与 Rho 信号通路结合，促进细胞迁移和增殖，从而促进胃黏膜伤口愈合。

(ii) Why you believe the manuscript will be of interest to the readers of Food Bioscience
（ii） 为什么您认为《食品生物科学》的读者会对这份手稿感兴趣

Recently, many researchers have found that various peptides have multiple biological activities, including anti-inflammation, anti-diabetes, anti-cancer, anti-osteoporosis, anti-multiple sclerosis. Nevertheless, the detailed mechanism of polypeptide in improving gastric mucosa injury repair is rarely reported.
最近，许多研究人员发现，各种肽具有多种生物活性，包括抗炎、抗糖尿病、抗癌、抗骨质疏松症、抗多发性硬化症。然而，多肽改善胃黏膜损伤修复的详细机制很少报道。

In this study, we are the first to report that the B1 component isolated from CGGE has a reparative effect on gastric mucosal damage and have elucidated its mechanism of action. The research findings can serve as a reference for the preparation and development of CGGE peptide products and their application in the repair of gastric mucosal damage.
在这项研究中，我们首次报道了从CGGE中分离出的B1成分对胃粘膜损伤具有修复作用，并阐明了其作用机制。研究结果可为CGGE多肽产品的制备和开发及其在胃黏膜损伤修复中的应用提供参考。

Thank you for reading and considering this manuscript for publication.
感谢您阅读并考虑出版这份手稿。

Sincerely,
真诚地

Professor. Bing Du
教授。杜冰

College of Food Science
食品科学学院

South China Agricultural University
华南农业大学

Email: dubing@scau.edu.cn
电子邮件： dubing@scau.edu.cn