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Investigating the physiological role of S199A and S199D mutants of PHF6 protein in T-cell acute lymphoblastic leukemia.
探讨PHF6蛋白S199A和S199D突变在T细胞急性淋巴细胞白血病中的生理作用。 Turkish Journal of Medical SciencesSCI升级版 医学4区SCI基础版 医学4区IF 1.2
Erdoğan G, Özeş ON, Küpesiz A, Yoldaş ŞB. Erdoğan G, et al. Turk J Med Sci. 2023 Aug 11;53(5):1234-1243. doi: 10.55730/1300-0144.5689. eCollection 2023. Turk J Med Sci. 2023. PMID: 38812997 Free PMC article.
NOTCH1 expression in T-cell development depends on plant homeodomain finger protein 6 (PHF6), which plays a tumor suppressor role in T-ALL. Several studies have shown that PHF6 expression is essential for NOTCH1 expression. ...RESULTS: The ectopic expression …
T细胞发育中的NOTCH 1表达取决于植物同源结构域指蛋白6（PHF 6），该蛋白在T-ALL中发挥肿瘤抑制作用。几项研究表明，PHF 6表达对于NOTCH 1表达至关重要。...结果：异位表达.
NOTCH1 expression in T-cell development depends on plant homeodomain finger protein 6 (PHF6), which plays a tumor suppressor r …
PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model.
PHF 6缺失降低了急性骨髓性白血病小鼠模型中的白血病干细胞活性。 Cancer Cell InternationalSCI升级版 医学2区SCI基础版 医学2区IF 5.3
Yuan S, Gao M, Wang Y, Lan Y, Li M, Du Y, Li Y, Ju W, Huang Y, Yuan K, Zeng L. Yuan S, et al. Cancer Cell Int. 2024 Feb 9;24(1):66. doi: 10.1186/s12935-024-03265-w. Cancer Cell Int. 2024. PMID: 38336746 Free PMC article.
In our study, we knocked out the Phf6 gene at different disease stages in the AML mice model. Moreover, we knocked down PHF6 by shRNA in two AML cell lines and examined the cell growth, apoptosis, and cell cycle. ...The expressions of genes related to cell different …
在我们的研究中，我们敲除了急性白血病小鼠模型中不同疾病阶段的Phf 6基因。此外，我们在两种急性白血病细胞系中通过HRA敲除PHF 6，并检查了细胞生长、细胞死亡和细胞周期。...与细胞不同相关的基因的表达.
In our study, we knocked out the Phf6 gene at different disease stages in the AML mice model. Moreover, we knocked down PHF6 b …
PHF6 maintains acute myeloid leukemia via regulating NF-kappaB signaling pathway.
PHF 6通过调节NF-kappaB信号途径维持急性骨髓性白血病。 Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 12.8
Hou S, Wang X, Guo T, Lan Y, Yuan S, Yang S, Zhao F, Fang A, Liu N, Yang W, Chu Y, Jiang E, Cheng T, Sun X, Yuan W. Hou S, et al. Leukemia. 2023 Aug;37(8):1626-1637. doi: 10.1038/s41375-023-01953-6. Epub 2023 Jul 1. Leukemia. 2023. PMID: 37393343 Free PMC article.
PHF6 depletion inhibited the NF-kappaB signaling pathways by disrupting the PHF6-p50 complex and partially inhibiting the nuclear translocation of p50 to suppress the expression of BCL2. ...Taken together, in contrast to PHF6 as a tumor suppressor in T …
PHF 6耗尽通过破坏PHF 6-p50复合物并部分抑制p50的核转运以抑制BCC 2的表达来抑制NF-kappaB信号途径。...总而言之，与PHF 6作为T.
PHF6 depletion inhibited the NF-kappaB signaling pathways by disrupting the PHF6-p50 complex and partially inhibiting the nucl …
Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs).
使用患者来源的诱导多能干细胞(IPSCs)模拟慢性髓系白血病(CML)的全球基因组不稳定性。 Cancers中科院预警 引用操纵SCI升级版 医学2区SCI基础版 医学2区IF 4.5
Telliam G, Desterke C, Imeri J, M'kacher R, Oudrhiri N, Balducci E, Fontaine-Arnoux M, Acloque H, Bennaceur-Griscelli A, Turhan AG. Telliam G, et al. Cancers (Basel). 2023 May 3;15(9):2594. doi: 10.3390/cancers15092594. Cancers (Basel). 2023. PMID: 37174060 Free PMC article.
CGH array performed for both conditions in two different time points reveals several cancer genes in the ENU-treated condition, some known to be altered in leukemia (BLM, IKZF1, NCOA2, ALK, EP300, ERG, MKL1, PHF6 and TET1). ...
在两种情况下在两个不同的时间点进行的CGH阵列显示了ENU治疗条件下的几个癌症基因，其中一些已知在白血病中发生了变化(BLM、IKZF1、NCOA2、ALK、EP300、ERG、MKL1、PHF6和TET1)。..。
CGH array performed for both conditions in two different time points reveals several cancer genes in the ENU-treated condition, some …
Next-Generation Sequencing-Based Genomic Profiling of Children with Acute Myeloid Leukemia.
基于下一代测序的儿童急性髓系白血病的基因组图谱。 Journal of Molecular DiagnosticsSCI升级版 医学3区SCI基础版 医学2区IF 3.4
Krizsán S, Péterffy B, Egyed B, Nagy T, Sebestyén E, Hegyi LL, Jakab Z, Erdélyi DJ, Müller J, Péter G, Csanádi K, Kállay K, Kriván G, Barna G, Bedics G, Haltrich I, Ottóffy G, Csernus K, Vojcek Á, Tiszlavicz LG, Gábor KM, Kelemen Á, Hauser P, Gaál Z, Szegedi I, Ujfalusi A, Kajtár B, Kiss C, Matolcsy A, Tímár B, Kovács G, Alpár D, Bödör C. Krizsán S, et al. J Mol Diagn. 2023 Aug;25(8):555-568. doi: 10.1016/j.jmoldx.2023.04.004. Epub 2023 Apr 22. J Mol Diagn. 2023. PMID: 37088137 Free PMC article.
Our study identified novel recurrent mutations at diagnosis in the BCORL1 gene in 9% of the patients. Tumor suppressor gene (PHF6, TP53, and WT1) mutations were found to be associated with induction failure and shorter event-free survival, suggesting important roles …
我们的研究发现，在9%的患者中，BCORL1基因在诊断时出现了新的反复突变。肿瘤抑制基因(PHF6、TP53和WT1)突变被发现与诱导失败和较短的无事件生存期有关，这表明…起着重要作用
Our study identified novel recurrent mutations at diagnosis in the BCORL1 gene in 9% of the patients. Tumor suppressor gene (PHF6 …
PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.
PHF6招募BPTF以促进YAP-High乳腺癌中HIF依赖的途径和进展。 Journal of Translational Medicine医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 6.1
Gao S, Zhang W, Ma J, Ni X. Gao S, et al. J Transl Med. 2023 Mar 26;21(1):220. doi: 10.1186/s12967-023-04031-8. J Transl Med. 2023. PMID: 36967443 Free PMC article.
PHF6 promotes Bca proliferation and migration. By analyzing The Cancer Genome Atlas breast cancer (TCGA-Bca) cohort, we found that PHF6 was significantly higher in tumor versus normal tissues. ...HIF-DKO abolished PHF6-mediated breast …
PHF6促进BCA的增殖和迁移。通过分析癌症基因组图谱乳腺癌(TCGA-BCA)队列，我们发现PHF6在肿瘤组织中明显高于正常组织。HIF-DKO取消PHF6介导的乳房….
PHF6 promotes Bca proliferation and migration. By analyzing The Cancer Genome Atlas breast cancer (TCGA-Bca) cohort, we …
PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T-cell infiltration.
PHF6通过促进癌细胞生长和减少T细胞的浸润而促进子宫内膜癌的进展。 Journal of Cellular And Molecular Medicine医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 4.3
Wang X, Fang A, Peng Y, Yu J, Yu C, Xie J, Zheng Y, Song L, Li P, Li J, Kang X, Lin Y, Li W. Wang X, et al. J Cell Mol Med. 2023 Mar;27(5):609-621. doi: 10.1111/jcmm.17638. Epub 2023 Feb 8. J Cell Mol Med. 2023. PMID: 36756714 Free PMC article.
The UCEC patients with high PHF6 expression had poor survival than UCEC patients with low PHF6 expression. PHF6 mutation occurred in 12% of UCEC patients, and PHF6 mutation predicted favourable clinical outcome in UCEC patients. ...
PHF 6高表达的UEC患者的生存率低于PHF 6低表达的UEC患者。12%的UEC患者发生PHF 6突变，PHF 6突变预示着UEC患者的良好临床结局。...
The UCEC patients with high PHF6 expression had poor survival than UCEC patients with low PHF6 expression. PHF6 mutatio …
Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model.
慢性髓系白血病(MBC-CML)的整合基因组测序，在白血病发生模型的背景下确定了潜在的重要发现。 Scientific ReportsSCI升级版 综合性期刊2区SCI基础版 综合性期刊3区IF 3.8
Kazemi-Sefat GE, Keramatipour M, Vaezi M, Razavi SM, Kavousi K, Talebi A, Rostami S, Yaghmaie M, Chahardouli B, Talebi S, Mousavizadeh K. Kazemi-Sefat GE, et al. Sci Rep. 2022 Jul 27;12(1):12816. doi: 10.1038/s41598-022-17232-w. Sci Rep. 2022. PMID: 35896598 Free PMC article.
An in-house filtering pipeline was applied to assess important variants in cancer-related genes. Standard variant interpretation guidelines were used for the interpretation of potentially important findings (PIFs) and potentially actionable findings (PAFs). Single nucleoti …
一条内部过滤管道被应用于评估癌症相关基因的重要变异。标准变式解释指南用于解释潜在重要发现(PIF)和潜在可诉讼发现(PAF)。单核细胞…
An in-house filtering pipeline was applied to assess important variants in cancer-related genes. Standard variant interpretation guid …
PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia.
PHF6通过将甲基转移酶SUV39H1募集到核仁区而发挥肿瘤抑制作用，为PHF6-Munant白血病提供了一个新的治疗靶点。 Acta Pharmaceutica Sinica b医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 14.7
Tsai HI, Wu Y, Huang R, Su D, Wu Y, Liu X, Wang L, Xu Z, Pang Y, Sun C, He C, Shu F, Zhu H, Wang D, Cheng F, Huang L, Chen H. Tsai HI, et al. Acta Pharm Sin B. 2022 Apr;12(4):1913-1927. doi: 10.1016/j.apsb.2021.10.025. Epub 2021 Oct 30. Acta Pharm Sin B. 2022. PMID: 35847518 Free PMC article.
The knockdown of either SUV39H1 or PHF6 significantly attenuated the effects of increase in H3K9me3 and suppressed the transcription of rDNA induced by the overexpression of the other interacting partner, thereby establishing an interdependent relationship between PHF6 …
SUV39H1或PHF6的敲除显著减弱了H3K9me3的增加效应，并抑制了由另一个相互作用伙伴的过度表达所诱导的rDNA的转录，从而建立了PHF6…之间的相互依赖关系
The knockdown of either SUV39H1 or PHF6 significantly attenuated the effects of increase in H3K9me3 and suppressed the transcription …
Genomic landscape of T-cell lymphoblastic lymphoma.
T细胞淋巴母细胞淋巴瘤的基因组图谱。 Chinese Journal of Cancer ResearchSCI升级版 医学2区SCI基础版 医学2区IF 7.0
Li Z, Song Y, Zhang M, Wei Y, Ruan H. Li Z, et al. Chin J Cancer Res. 2022 Apr 30;34(2):83-94. doi: 10.21147/j.issn.1000-9604.2022.02.03. Chin J Cancer Res. 2022. PMID: 35685993 Free PMC article.
Notably, besides notch receptor 1 (NOTCH1), mutational status of plant homeodomain (PHD)-like finger protein 6 (PHF6) was identified as another independent factor for good prognosis. Of utmost interest is that co-existence of PHF6 and NOTCH1 mutation status might pr …
值得注意的是，除了notch受体1（NOTCH 1）之外，植物同源结构域（PHD）样手指蛋白6（PHF 6）的突变状态被确定为良好预后的另一个独立因素。最有趣的是，PHF 6和NOTCH 1突变状态的共存可能会导致.
Notably, besides notch receptor 1 (NOTCH1), mutational status of plant homeodomain (PHD)-like finger protein 6 (PHF6) was identified …
Transcriptional expressions of hsa-mir-183 predicted target genes as independent indicators for prognosis in bladder urothelial carcinoma.
Hsa-mir-183转录表达预测膀胱尿路上皮癌预后的独立指标。 Aging-usSCI升级版 医学3区SCI基础版 医学2区IF 3.9
Li M, Xu DM, Lin SB, Yang ZL, Xu TY, Yang JH, Lin ZX, Huang ZK, Yin J. Li M, et al. Aging (Albany NY). 2022 May 3;14(9):3782-3800. doi: 10.18632/aging.204040. Epub 2022 May 3. Aging (Albany NY). 2022. PMID: 35503998 Free PMC article.
METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases. RESULTS: …
方法：本研究通过UALCAN、Metascape、Kaplan-Meier绘图仪、人类蛋白质图谱、TIMER2.0、生物门户网站和肿瘤药敏基因组数据库，探讨hsa-mir-183预测靶基因在BLCA预后中的作用。结果：…
METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Meta …
Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair.
PHF 6复合物在染色质重塑、复制动力学和DNA修复中的功能绘图。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 21.0
Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, A Ferrando A. Alvarez S, et al. Blood. 2022 Jun 9;139(23):3418-3429. doi: 10.1182/blood.2021014103. Blood. 2022. PMID: 35338774 Free PMC article.
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation. However, specific molecular mechanisms controlled by PHF6 remain rudimentarily understood. Here we show …
植物同源域6基因(PHF6)编码核仁和染色质相关的白血病肿瘤抑制因子，被认为在转录调控中发挥作用。然而，由PHF6控制的特定分子机制仍被初步了解。在这里我们向…展示
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles …
Somatic Mutational Profile of High-Grade Serous Ovarian Carcinoma and Triple-Negative Breast Carcinoma in Young and Elderly Patients: Similarities and Divergences.
青年和老年高级别浆液性卵巢癌和三阴性乳腺癌患者的体细胞突变特征：异同。 CellsSCI升级版 生物学2区SCI基础版 生物2区IF 5.1
Serio PAMP, de Lima Pereira GF, Katayama MLH, Roela RA, Maistro S, Folgueira MAAK. Serio PAMP, et al. Cells. 2021 Dec 20;10(12):3586. doi: 10.3390/cells10123586. Cells. 2021. PMID: 34944094 Free PMC article.
BACKGROUND: Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that share similarities; however, different ages of onset may reflect distinct tumor behaviors. ...METHODS: Open access mutational data ( …
背景：三阴性乳腺癌(TNBC)和高级别浆液性卵巢癌(HGSOC)是具有相似性的侵袭性恶性肿瘤，但不同的发病年龄可能反映不同的肿瘤行为。方法：开放存取突变数据(…
BACKGROUND: Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that …
LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer.
LINC00958/miR-3174/PHF6轴与子宫内膜癌的增殖、迁移和侵袭有关。 European Review For Medical And Pharmacological SciencesSCI升级版 医学4区SCI基础版 医学3区
欧洲医学和药理学评论SCI升级版医学4区SCI基础版医学3区
Li QY, Shen JQ, Li JH, Dai DF, Saeed M, Li CX. Li QY, et al. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):6853-6861. doi: 10.26355/eurrev_202111_27233. Eur Rev Med Pharmacol Sci. 2021. PMID: 34859848 Free article.
Dual-Luciferase reporter assay was carried out to identify the LINC00958/miR-3174/PHF6 axis, and their expression interaction was determined by Pearson correlation test. ...It stimulates EC to proliferate, migrate and invade through the miR-3174/PHF6 axis....
采用双荧光素酶报告基因检测LINC00958/miR-3174/PHF6轴，通过Pearson相关性检验确定其表达相互作用。...通过miR-3174/PHF6轴刺激EC增殖、迁移和侵袭.
Dual-Luciferase reporter assay was carried out to identify the LINC00958/miR-3174/PHF6 axis, and their expression interaction was det …
PHF6 Mutations in Hematologic Malignancies.
血液系统恶性肿瘤中PHF6基因突变的研究 Frontiers in OncologySCI升级版 医学3区SCI基础版 医学2区IF 3.5
Kurzer JH, Weinberg OK. Kurzer JH, et al. Front Oncol. 2021 Jul 26;11:704471. doi: 10.3389/fonc.2021.704471. eCollection 2021. Front Oncol. 2021. PMID: 34381727 Free PMC article. Review.
PHF6 serves as a tumor suppressor protein, with PHF6 mutations and deletions often implicated in the development of T-lymphoblastic leukemia and less frequently in acute myeloid leukemia and other myeloid neoplasms. ...Due to conflicting data, the prognostic …
PHF 6是一种肿瘤抑制蛋白，PHF 6突变和缺失通常与T淋巴细胞白血病的发生有关，而在急性骨髓性白血病和其他骨髓性肿瘤中则不太常见。...由于数据相互矛盾，预后.
PHF6 serves as a tumor suppressor protein, with PHF6 mutations and deletions often implicated in the development of T-l …
Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation.
Notocumab R1通过PHF 6蛋白诱导DNA损伤，抑制宫颈癌细胞的生长。 Molecular Medicine ReportsSCI升级版 医学3区SCI基础版 医学4区IF 3.4
Cai T, Wu W, Guo L, Xia Y, Jiang X, Zhang L, Peng F, Ming P. Cai T, et al. Mol Med Rep. 2021 Apr;23(4):242. doi: 10.3892/mmr.2021.11881. Epub 2021 Feb 4. Mol Med Rep. 2021. PMID: 33537816 Free PMC article.
Notoginsenoside R1 (NGR1), a monomer of Traditional Chinese medicine, is from the Panax notoginsenoside complex, and has been reported to inhibit the proliferation of various types of cancer. However the mechanism underlying NGR1-mediated inhibition of cervical carcinoma c …
三七素R1（NGR 1）是一种中药单体，来自三七复合物，据报道可以抑制各种类型癌症的扩散。然而，NGR 1介导的宫颈癌抑制作用的机制。
Notoginsenoside R1 (NGR1), a monomer of Traditional Chinese medicine, is from the Panax notoginsenoside complex, and has been reported to in …
Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.
儿童B细胞前体急性淋巴细胞性白血病的驱动基因突变及其临床影响。 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.4
Ueno H, Yoshida K, Shiozawa Y, Nannya Y, Iijima-Yamashita Y, Kiyokawa N, Shiraishi Y, Chiba K, Tanaka H, Isobe T, Seki M, Kimura S, Makishima H, Nakagawa MM, Kakiuchi N, Kataoka K, Yoshizato T, Nishijima D, Deguchi T, Ohki K, Sato A, Takahashi H, Hashii Y, Tokimasa S, Hara J, Kosaka Y, Kato K, Inukai T, Takita J, Imamura T, Miyano S, Manabe A, Horibe K, Ogawa S, Sanada M. Ueno H, et al. Blood Adv. 2020 Oct 27;4(20):5165-5173. doi: 10.1182/bloodadvances.2019001307. Blood Adv. 2020. PMID: 33095873 Free PMC article.
In addition, positive correlations were also newly reported between TCF3-PBX1 ALL with PHF6 mutations. In multivariate Cox proportional hazards regression models for overall survival, TP53 mutation/deletion, hypodiploid, and MEF2D fusions were selected in both cohorts. ... …
此外，最近还报道了TCF3-Pbx1与PHF6突变之间的正相关。在总体生存的多变量Cox比例风险回归模型中，两组均选择了TP53突变/缺失、亚二倍体和MEF2D融合。...…
In addition, positive correlations were also newly reported between TCF3-PBX1 ALL with PHF6 mutations. In multivariate Cox proportion …
Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse.
监测急性骨髓性白血病的克隆进化可以识别白血病亚型、临床结局和缓解后策略或复发的潜在新药靶点。 Haematologica医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 8.2
Onecha E, Rapado I, Luz Morales M, Carreño-Tarragona G, Martinez-Sanchez P, Gutierrez X, Sáchez Pina JM, Linares M, Gallardo M, Martinez-López J, Ayala R. Onecha E, et al. Haematologica. 2021 Sep 1;106(9):2325-2333. doi: 10.3324/haematol.2020.254623. Haematologica. 2021. PMID: 32732356 Free PMC article.
The most frequently affected pathways in patients with primary refractoriness were signaling, transcription and tumor suppression, whereas methylation and splicing pathways were mainly implicated in relapsed patients. ...Specifically, 100% of variants in EZH2, RUNX1, VHL, …
在初次不治性患者中，最常受影响的途径是信号传递、转录和肿瘤抑制，而甲基化和拼接途径主要涉及复发患者。...具体来说，EZH2、RUNX 1、VHL、.中100%的变体
The most frequently affected pathways in patients with primary refractoriness were signaling, transcription and tumor suppression, wh …
Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery.
染色质调节剂及其对DNA修复和G2检查点恢复的影响。 Cell CycleSCI升级版 生物学3区SCI基础版 生物3区IF 3.4
Smits VAJ, Alonso-de Vega I, Warmerdam DO. Smits VAJ, et al. Cell Cycle. 2020 Sep;19(17):2083-2093. doi: 10.1080/15384101.2020.1796037. Epub 2020 Jul 30. Cell Cycle. 2020. PMID: 32730133 Free PMC article. Review.
We recently performed a reverse genetic screen for novel chromatin regulators that control checkpoint recovery after DNA damage. Here we discuss the implications of PHD finger protein 6 (PHF6) and additional candidates from the NuA4 ATPase-dependent chromatin-remodeling co …
我们最近对控制DNA损伤后检查点恢复的新型染色质调节剂进行了反向遗传筛选。在这里，我们讨论了PhD Finger Protein 6(PHF6)和NuA4ATPase依赖的染色质重塑联合…的其他候选基因的含义
We recently performed a reverse genetic screen for novel chromatin regulators that control checkpoint recovery after DNA damage. Here we dis …
Clinicopathological Characteristics and Mutational Profiling of Adult T-Cell Lymphoblastic Lymphoma in a Chinese Population.
中国人群成人T细胞淋巴瘤的临床病理特征和突变特征。 Cancer Management And ResearchSCI升级版 医学4区SCI基础版 医学3区IF 2.5
Chen F, Pang D, Guo H, Jiang X, Liu S, Huang L, Wei X, Liang Z, Wang X, Li W. Chen F, et al. Cancer Manag Res. 2020 Apr 30;12:3003-3012. doi: 10.2147/CMAR.S242903. eCollection 2020. Cancer Manag Res. 2020. PMID: 32431543 Free PMC article.
Chidamide maintenance was used in five patients exhibiting unfavorable genetic alterations, with no evidence of relapse. Next-generation sequencing of pretreatment tumor tissue was undertaken for 15 patients. NOTCH1 mutations were the most frequent genetic alterations, fol …
五名表现出不利基因改变的患者使用了奇达胺维持治疗，没有复发的证据。对15名患者进行了治疗前肿瘤组织的下一代测序。NOTCH 1突变是最常见的遗传改变，如.
Chidamide maintenance was used in five patients exhibiting unfavorable genetic alterations, with no evidence of relapse. Next-generation seq …
Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing.
应用外显子测序技术分析中国地区儿童急性淋巴细胞白血病单中心基因突变 Bmc Cancer医学TOPSCI升级版 医学2区SCI基础版 医学3区IF 3.4
Zhang H, Wang H, Qian X, Gao S, Xia J, Liu J, Cheng Y, Man J, Zhai X. Zhang H, et al. BMC Cancer. 2020 Mar 12;20(1):211. doi: 10.1186/s12885-020-6709-7. BMC Cancer. 2020. PMID: 32164600 Free PMC article.
METHODS: Using next-generation sequencing (NGS) in matched germline and tumor samples from 140 pediatric Chinese patients with ALL, we landscaped the gene mutations and estimated the mutation frequencies in this disease. ...While the most frequently mutated genes were KRAS …
方法：应用下一代测序技术(NGS)对140例ALL患儿的配对种系和肿瘤标本进行基因突变分析，并估算其突变频率。.而突变最频繁的基因是KRAS…
METHODS: Using next-generation sequencing (NGS) in matched germline and tumor samples from 140 pediatric Chinese patients with ALL, w …
Rapid Identification of Key Copy Number Alterations in B- and T-Cell Acute Lymphoblastic Leukemia by Digital Multiplex Ligation-Dependent Probe Amplification.
通过数字多重连接依赖性探针放大快速识别B细胞和T细胞急性淋巴细胞白血病的关键拷贝数改变。 Frontiers in OncologySCI升级版 医学3区SCI基础版 医学2区IF 3.5
Thakral D, Kaur G, Gupta R, Benard-Slagter A, Savola S, Kumar I, Anand R, Rani L, Verma P, Joshi S, Kumar L, Sharma A, Bakhshi S, Seth R, Singh V. Thakral D, et al. Front Oncol. 2019 Sep 13;9:871. doi: 10.3389/fonc.2019.00871. eCollection 2019. Front Oncol. 2019. PMID: 31572674 Free PMC article.
Heterozygous and homozygous gene deletions, and duplications were observed in genes involved in cell cycle control, tumor suppression, lineage differentiation, lymphoid signaling, and transcriptional regulators with implications in treatment response and survival outcome. …
在参与细胞周期控制、肿瘤抑制、谱系分化、淋巴信号传递和转录调节因子的基因中观察到杂合和纯合基因缺失和重复，这对治疗反应和生存结果有影响。…
Heterozygous and homozygous gene deletions, and duplications were observed in genes involved in cell cycle control, tumor suppression …
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.
人类恶性生殖细胞肿瘤细胞系的蛋白质组学比较。 Disease MarkersSCI基础版 医学3区
Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F. Bremmer F, et al. Dis Markers. 2019 Sep 3;2019:8298524. doi: 10.1155/2019/8298524. eCollection 2019. Dis Markers. 2019. PMID: 31565104 Free PMC article.
We were able to identify 4856 proteins and quantify the expression of 3936. 347 were significantly differentially expressed between the two cell lines. For further validation, CD81, CBX-3, PHF6, and ENSA were analyzed by western blot analysis. The results confirmed the MS …
我们能够识别4856种蛋白质并量化3936种蛋白质的表达。347在两种细胞系之间存在显着差异表达。为了进一步验证，通过蛋白质印记分析分析了CD 81、CBX-3、PHF 6和ENSA。结果证实MS.
We were able to identify 4856 proteins and quantify the expression of 3936. 347 were significantly differentially expressed between the two …
Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia.
PTPN2缺失成人和儿童T细胞急性淋巴细胞白血病的临床和生物学特征 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.4
Alcantara M, Simonin M, Lhermitte L, Touzart A, Dourthe ME, Latiri M, Grardel N, Cayuela JM, Chalandon Y, Graux C, Dombret H, Ifrah N, Petit A, Macintyre E, Baruchel A, Boissel N, Asnafi V. Alcantara M, et al. Blood Adv. 2019 Jul 9;3(13):1981-1988. doi: 10.1182/bloodadvances.2018028993. Blood Adv. 2019. PMID: 31270080 Free PMC article.
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphoblastic leukemia (T-ALL). ...Analysis of the mutational genotype of adult T-ALL revealed a positive correlation between PTPN2 deletions and ga …
蛋白酪氨酸磷酸酶非受体2(PTPN2)是一种磷酸酶，是T细胞急性淋巴细胞性白血病(T-ALL)的抑癌基因。对成人T-ALL突变型的分析显示，PTPn2缺失与ga…呈正相关.
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphobl …
Context-specific tumor suppression by PHF6.
PHF6对特定背景肿瘤的抑制作用。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 21.0
Trowbridge JJ. Trowbridge JJ. Blood. 2019 Apr 18;133(16):1698-1700. doi: 10.1182/blood-2019-03-900829. Blood. 2019. PMID: 31000514 Free PMC article.
In this issue of Blood, McRae et al report that loss of plant homeodomain finger 6 (Phf6) increases the ability of hematopoietic stem and progenitor cells (HSPCs) to sustain long-term engraftment and can specifically synergize with the oncogenic homeobox transcription fact …
在本期《血液》杂志中，McRae等人报道，植物同源结构域Fing6(PhF6)的缺失增加了造血干细胞和祖细胞(HSPC)维持长期植入的能力，并可以与致癌的同源盒转录因子…特异性地协同作用
In this issue of Blood, McRae et al report that loss of plant homeodomain finger 6 (Phf6) increases the ability of hematopoietic stem …
The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
染色质结合蛋白Phf6限制了造血干细胞的自我更新。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 21.0
Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A. Miyagi S, et al. Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27. Blood. 2019. PMID: 30917958 Free article.
However, the role of PHF6 in normal hematopoiesis and its tumor-suppressor function remain largely unknown. ...Mechanistically, Phf6 directly and indirectly activated downstream effectors in tumor necrosis factor alpha (TNFalpha) signaling. ...
然而，PHF6在正常造血中的作用及其肿瘤抑制功能在很大程度上仍不清楚。从机制上讲，Phf6直接和间接激活了肿瘤坏死因子α(TNFpha)信号的下游效应...。
However, the role of PHF6 in normal hematopoiesis and its tumor-suppressor function remain largely unknown. ...Mechanistically …
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
PHF6调节造血干/祖细胞，其缺失与TLX3的表达协同作用，导致白血病的发生。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 21.0
McRae HM, Garnham AL, Hu Y, Witkowski MT, Corbett MA, Dixon MP, May RE, Sheikh BN, Chiang W, Kueh AJ, Nguyen TA, Man K, Gloury R, Aubrey BJ, Policheni A, Di Rago L, Alexander WS, Gray DHD, Strasser A, Hawkins ED, Wilcox S, Gécz J, Kallies A, McCormack MP, Smyth GK, Voss AK, Thomas T. McRae HM, et al. Blood. 2019 Apr 18;133(16):1729-1741. doi: 10.1182/blood-2018-07-860726. Epub 2019 Feb 12. Blood. 2019. PMID: 30755422 Free PMC article.
Loss of PHF6 caused increased and sustained hematopoietic reconstitution in serial transplantation experiments. ...Ectopic expression of TLX3 alone caused partially penetrant leukemia. TLX3 expression and loss of PHF6 combined caused fully penetrant early-onset leuk …
在系列移植实验中，PHF6的缺失导致了造血重建的增加和持续。TLX3的异位表达单独引起部分穿透性白血病.TLX3的表达和丢失联合PHF6导致的全透性早发性…
Loss of PHF6 caused increased and sustained hematopoietic reconstitution in serial transplantation experiments. ...Ectopic expression …
Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically.
新发急性粒细胞白血病的复杂染色体组型：典型和非典型亚型在分子和临床上存在差异。 Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 12.8
Mrózek K, Eisfeld AK, Kohlschmidt J, Carroll AJ, Walker CJ, Nicolet D, Blachly JS, Bill M, Papaioannou D, Wang ES, Uy GL, Kolitz JE, Powell BL, Blum W, Stone RM, Byrd JC, Bloomfield CD. Mrózek K, et al. Leukemia. 2019 Jul;33(7):1620-1634. doi: 10.1038/s41375-019-0390-3. Epub 2019 Feb 8. Leukemia. 2019. PMID: 30737482 Free PMC article.
Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated genes in 160 clinically well-characterized patients. ...Patients with atypical CK-AML differed from those with typical CK-AML: they carried TP5 …
由于CK-APL的分子特征尚未得到很好的描述，我们研究了160名临床特征良好的患者中81个白血病/癌症相关基因的突变状态。...患有非典型CK-AML的患者与患有典型CK-AML的患者不同：他们携带TP 5.
Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated gen …
Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL.
Phf 6缺失增强了RSC自我更新，推动T-ALL中的肿瘤发生和白血病干细胞活性。 Cancer Discovery医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 29.7
Wendorff AA, Quinn SA, Rashkovan M, Madubata CJ, Ambesi-Impiombato A, Litzow MR, Tallman MS, Paietta E, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Rabadan R, Van Vlierberghe P, Ferrando AA. Wendorff AA, et al. Cancer Discov. 2019 Mar;9(3):436-451. doi: 10.1158/2159-8290.CD-18-1005. Epub 2018 Dec 19. Cancer Discov. 2019. PMID: 30567843 Free PMC article.
Consistent with a leukemia-initiating tumor suppressor role, inactivation of Phf6 in hematopoietic progenitors lowers the threshold for the development of NOTCH1-induced T-ALL. ...These results implicate Phf6 in the control of HSC homeostasis and long-term se …
与白血病引发的肿瘤抑制作用一致，Phf 6在骨髓祖细胞中的失活会降低NOTCH 1诱导的T-ALL发生的阈值。...这些结果表明Phf 6参与了OSC稳态和长期稳定的控制.
Consistent with a leukemia-initiating tumor suppressor role, inactivation of Phf6 in hematopoietic progenitors lowers the thre …
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.
PHF6和DNMT3A突变在具有T系分化的混合表型急性白血病的不同亚群中丰富。 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.4
Xiao W, Bharadwaj M, Levine M, Farnhoud N, Pastore F, Getta BM, Hultquist A, Famulare C, Medina JS, Patel MA, Gao Q, Lewis N, Pichardo J, Baik J, Shaffer B, Giralt S, Rampal R, Devlin S, Cimera R, Zhang Y, E Arcila M, Papaemmanuil E, Levine RL, Roshal M. Xiao W, et al. Blood Adv. 2018 Dec 11;2(23):3526-3539. doi: 10.1182/bloodadvances.2018023531. Blood Adv. 2018. PMID: 30530780 Free PMC article.
These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked predilection for T-lineage differentiation (5/6 PHF6 mutated, 6/6 DNMT3A mutated). ...Sequencing studies on flow-cytometry-sorted popula …
这些突变和BCR-ABL1/MLL易位是相互排斥的。PHF6和DNMT3A突变的MPAL表现出明显的T系分化倾向(5/6 PHF6突变，6/6 DNMT3A突变)。流式细胞术分选群体…的测序研究.
These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked pre …
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.
B/T混合表型急性白血病的基因组和临床特征表现为复发和T-ALL样突变。 American Journal of Hematology医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 10.1
Mi X, Griffin G, Lee W, Patel S, Ohgami R, Ok CY, Wang S, Geyer JT, Xiao W, Roshal M, Garcia JS, Silverman LB, Sallan SE, Aster JC, Harris MH, Weinberg OK. Mi X, et al. Am J Hematol. 2018 Nov;93(11):1358-1367. doi: 10.1002/ajh.25256. Epub 2018 Sep 26. Am J Hematol. 2018. PMID: 30117174 Free PMC article.
While the tumors have diverse cytogenetic and genomic perturbations, recurrent acquired aberrations include mutations in the putative transcriptional regulator PHF6 and the JAK-STAT and Ras signaling pathways. Alterations were also identified in genes encoding hematopoieti …
虽然肿瘤具有不同的细胞遗传学和基因组扰动，但反复出现的获得性异常包括假定的转录调节因子PHF6以及JAK-STAT和RAS信号通路的突变。编码造血酶…的基因也发生了变化
While the tumors have diverse cytogenetic and genomic perturbations, recurrent acquired aberrations include mutations in the putative transc …
Clinical and molecular predictors of long-term response in HER2 positive metastatic breast cancer patients.
HER2阳性转移性乳腺癌患者长期疗效的临床和分子预测因素。 Cancer Biology & TherapySCI升级版 医学4区SCI基础版 医学3区IF 4.4
Omarini C, Bettelli S, Caprera C, Manfredini S, Caggia F, Guaitoli G, Moscetti L, Toss A, Cortesi L, Kaleci S, Maiorana A, Cascinu S, Conte PF, Piacentini F. Omarini C, et al. Cancer Biol Ther. 2018;19(10):879-886. doi: 10.1080/15384047.2018.1480287. Epub 2018 Aug 1. Cancer Biol Ther. 2018. PMID: 30067438 Free PMC article.
BACKGROUND: HER2+ metastatic breast cancer (MBC) is a poor prognosis disease, unusually curable. To date, no predictive factors have been clearly correlated with long-term response to anti-HER2 agents. ...Further clinical implications are warranted. ABBREVIATIONS: BC: brea …
背景：HER2+转移性乳腺癌(MBC)是一种预后较差的疾病，极难治愈。到目前为止，还没有预测因素与抗HER2药物的长期反应明显相关。...进一步的临床影响是有保证的。缩写：BC：BREA…
BACKGROUND: HER2+ metastatic breast cancer (MBC) is a poor prognosis disease, unusually curable. To date, no predictive factors have …
3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.
3 ' UTR缩短通过破坏ceRNA串烧来抑制反式肿瘤抑制基因。 Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 31.7
Park HJ, Ji P, Kim S, Xia Z, Rodriguez B, Li L, Su J, Chen K, Masamha CP, Baillat D, Fontes-Garfias CR, Shyu AB, Neilson JR, Wagner EJ, Li W. Park HJ, et al. Nat Genet. 2018 Jun;50(6):783-789. doi: 10.1038/s41588-018-0118-8. Epub 2018 May 21. Nat Genet. 2018. PMID: 29785014 Free PMC article.
MAT3UTR predicts many trans-targets of 3' UTR shortening, including PTEN, a crucial tumor-suppressor gene (3) involved in ceRNA crosstalk (4) with nine 3'UTR-shortening genes, including EPS15 and NFIA. Knockdown of NUDT21, a master 3' UTR-shortening regulator (2) , repress …
MAT 3UTR预测了3 ' UTR缩短的许多反式靶点，包括PEN，这是一种参与ceRNA串话（4）的关键肿瘤抑制基因（3），包括EPS 15和NFIA。3 ' UTR缩短大师级调节器NUDT 21的淘汰（2），压制.
MAT3UTR predicts many trans-targets of 3' UTR shortening, including PTEN, a crucial tumor-suppressor gene (3) involved in ceRNA cross …
Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 Study Group.
分子分析定义儿童急性白血病中不同预后亚组：法国ELAM 02研究小组的报告。 HemasphereSCI升级版 医学2区IF 7.6
Marceau-Renaut A, Duployez N, Ducourneau B, Labopin M, Petit A, Rousseau A, Geffroy S, Bucci M, Cuccuini W, Fenneteau O, Ruminy P, Nelken B, Ducassou S, Gandemer V, Leblanc T, Michel G, Bertrand Y, Baruchel A, Leverger G, Preudhomme C, Lapillonne H. Marceau-Renaut A, et al. Hemasphere. 2018 Feb 21;2(1):e31. doi: 10.1097/HS9.0000000000000031. eCollection 2018 Jan-Feb. Hemasphere. 2018. PMID: 31723759 Free PMC article.
The most common class of mutations involved genes that control kinase signaling (61%) followed by transcription factors (16%), tumor suppressors (14%), chromatin modifiers (9%), DNA methylation controllers (8%), cohesin genes (5%), and spliceosome (3%). ...Overall, CBF rea …
最常见的突变类型涉及控制Kinase信号传递的基因（61%），其次是转录因子（16%）、肿瘤抑制因子（14%）、染色质修饰物（9%）、DNA甲基化控制器（8%）、粘着素基因（5%）和拼接体（3%）。...总体而言，CBF确实.
The most common class of mutations involved genes that control kinase signaling (61%) followed by transcription factors (16%), tumor …
The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.
结直肠癌中肿瘤抑制基因、癌基因和miRNAs的共同调控网络。 Genes Chromosomes & CancerSCI升级版 医学2区SCI基础版 医学3区IF 3.1
Slattery ML, Herrick JS, Mullany LE, Samowitz WS, Sevens JR, Sakoda L, Wolff RK. Slattery ML, et al. Genes Chromosomes Cancer. 2017 Nov;56(11):769-787. doi: 10.1002/gcc.22481. Epub 2017 Jul 30. Genes Chromosomes Cancer. 2017. PMID: 28675510 Free PMC article.
Tumor suppressor genes (TSGs) and oncogenes (OG) are involved in carcinogenesis. MiRNAs also contribute to cellular pathways leading to cancer. We use data from 217 colorectal cancer (CRC) cases to evaluate differences in TSGs and OGs expression between paire …
肿瘤抑制基因(TSG)和癌基因(OG)参与肿瘤的发生。MiRNAs也参与了导致癌症的细胞途径。我们使用217例结直肠癌患者的数据来评估配对…在TSG和OGs表达上的差异
Tumor suppressor genes (TSGs) and oncogenes (OG) are involved in carcinogenesis. MiRNAs also contribute to cellular pathways leading …
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.
PHF 6通过谱系特异性基因内的染色质组织调节表型可塑性。 Genes & Development生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 7.5
Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sánchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. Soto-Feliciano YM, et al. Genes Dev. 2017 May 15;31(10):973-989. doi: 10.1101/gad.295857.117. Epub 2017 Jun 12. Genes Dev. 2017. PMID: 28607179 Free PMC article.
Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific transcription factors. We show that loss of Phf6 in B-cell leukemia results in systematic change …
在这里，我们描述了植物同域指蛋白6（PHF 6）在白血病中的功能，并定义了其在调节染色质对谱系特异性转录因子的可及性方面的作用。我们表明B细胞白血病中Phf 6的缺失会导致系统性变化..
Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromat …
Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.
儿童T细胞急性淋巴细胞性白血病的基因组特征揭示了新的复发驱动突变。 Oncotarget
Spinella JF, Cassart P, Richer C, Saillour V, Ouimet M, Langlois S, St-Onge P, Sontag T, Healy J, Minden MD, Sinnett D. Spinella JF, et al. Oncotarget. 2016 Oct 4;7(40):65485-65503. doi: 10.18632/oncotarget.11796. Oncotarget. 2016. PMID: 27602765 Free PMC article.
Using an integrative approach combining genomic and transcriptomic data, we molecularly characterized 30 pediatric T-ALLs and identified common recurrent T-ALL targets such as FBXW7, JAK1, JAK3, PHF6, KDM6A and NOTCH1 as well as novel candidate T-ALL driver mutations inclu …
采用基因组和转录组数据相结合的综合方法，我们对30个儿科T-ALL进行了分子表征，并鉴定了常见的复发T-ALL靶点，如FBXW7、JAK1、JAK3、PHF6、KDM6A和NOTCH1以及包括…在内的新的候选T-ALL驱动突变
Using an integrative approach combining genomic and transcriptomic data, we molecularly characterized 30 pediatric T-ALLs and identified com …
Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia.
成人T细胞急性淋巴细胞白血病中PHF6和NOTCH1突变共存 Oncology LettersSCI升级版 医学4区SCI基础版 医学4区IF 2.5
Li M, Xiao L, Xu J, Zhang R, Guo J, Olson J, Wu Y, Li J, Song C, Ge Z. Li M, et al. Oncol Lett. 2016 Jul;12(1):16-22. doi: 10.3892/ol.2016.4581. Epub 2016 May 16. Oncol Lett. 2016. PMID: 27347093 Free PMC article.
T-cell acute lymphoblastic leukemia (T-ALL) results from the collaboration of multiple genetic abnormalities in the transformation of T-cell progenitors. Plant homeodomain finger protein 6 (PHF6) has recently been established as a key tumor suppressor, which is muta …
T细胞急性淋巴细胞白血病(T-ALL)是T细胞前体细胞转化过程中多种基因异常协同作用的结果。植物同源结构域手指蛋白6(Phf6)是近年来发现的一种重要的肿瘤抑制因子，它是一种突变的…
T-cell acute lymphoblastic leukemia (T-ALL) results from the collaboration of multiple genetic abnormalities in the transformation of T-cell …
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. Genes & Development生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 7.5
基因组规模的体内功能丧失筛查确定Phf6是白血病细胞生长的谱系特异性调节因子。基因与发育生物学TOPSCI升级版生物学1区SCI基础版生物1区IF 7.5
Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. Meacham CE, et al. Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114. Genes Dev. 2015. PMID: 25737277 Free PMC article.
These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in human myeloid and T-cell malignancies, we found that Phf6 suppression in B-cell malignancies impairs tumor progression. Thus, …
其中包括编码锌指蛋白Phf 6的基因。虽然在人类骨髓和T细胞恶性肿瘤中经常观察到PHF 6的失活突变，但我们发现B细胞恶性肿瘤中的Phf 6抑制会损害肿瘤进展。因此，.
These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in h …
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis. Scientific ReportsSCI升级版 综合性期刊2区SCI基础版 综合性期刊3区IF 3.8
通过整合miRNA/mRNA调控网络分析确定胶质母细胞瘤中替莫唑胺耐药因素。科学报告SCI升级版综合性期刊2区SCI基础版综合性期刊3区IF 3.8
Hiddingh L, Raktoe RS, Jeuken J, Hulleman E, Noske DP, Kaspers GJ, Vandertop WP, Wesseling P, Wurdinger T. Hiddingh L, et al. Sci Rep. 2014 Jun 11;4:5260. doi: 10.1038/srep05260. Sci Rep. 2014. PMID: 24919120 Free PMC article.
Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 expression in three TMZ-resistant subclones significantly enhanced TMZ-induced cell kill in two of these cell lines. ...
对PHF6表达的分析表明，与正常组织相比，胶质母细胞瘤中PHF6的表达显著上调。干扰三个TMZ抗性亚克隆中PHF6的表达显著增强了TMZ诱导的其中两个细胞系的细胞杀伤。..。
Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 …
MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia. Haematologica医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 8.2
MicroRNA-128-3p是针对PHF6治疗T细胞急性淋巴细胞白血病的一种新的肿瘤标志物。血液学医学TOPSCI升级版医学1区SCI基础版医学1区IF 8.2
Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P, Benoit Y, De Moerloose B, Van Roy N, Poppe B, Vandesompele J, Wendel HG, Van Vlierberghe P, Speleman F, Rondou P. Mets E, et al. Haematologica. 2014 Aug;99(8):1326-33. doi: 10.3324/haematol.2013.099515. Epub 2014 Jun 3. Haematologica. 2014. PMID: 24895337 Free PMC article.
In this context, our previous description of a cooperative microRNA regulatory network controlling several well-known T-cell acute lymphoblastic leukemia tumor suppressor genes, including PHF6, is of great importance. Given the high frequency of PHF6 lesions …
在此背景下，我们之前对控制几种众所周知的T细胞急性淋巴细胞白血病肿瘤抑制基因（包括PHF 6）的合作微RNA调节网络的描述非常重要。鉴于PHF 6病变的频率很高.
In this context, our previous description of a cooperative microRNA regulatory network controlling several well-known T-cell acute lymphobla …
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes. Nature Communications综合性期刊TOPSCI升级版 综合性期刊1区SCI基础版 综合性期刊1区IF 14.7
1,000个儿科癌症基因组中表观遗传调控因子的体细胞突变图景。Natural Communications综合性期刊TOPSCI升级版综合性期刊1区SCI基础版综合性期刊1区IF 14.7
Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson MN, Hedlund EK, Rusch MC, Shurtleff SA, Mulder HL, Boggs K, Vadordaria B, Cheng J, Yergeau D, Song G, Becksfort J, Lemmon G, Weber C, Cai Z, Dang J, Walsh M, Gedman AL, Faber Z, Easton J, Gruber T, Kriwacki RW, Partridge JF, Ding L, Wilson RK, Mardis ER, Mullighan CG, Gilbertson RJ, Baker SJ, Zambetti G, Ellison DW, Zhang J, Downing JR. Huether R, et al. Nat Commun. 2014 Apr 8;5:3630. doi: 10.1038/ncomms4630. Nat Commun. 2014. PMID: 24710217 Free PMC article.
The most frequently mutated genes are H3F3A, PHF6, ATRX, KDM6A, SMARCA4, ASXL2, CREBBP, EZH2, MLL2, USP7, ASXL1, NSD2, SETD2, SMC1A and ZMYM3. ...Collectively, our results help to define the landscape of mutations in epigenetic regulatory genes in paediatric cancer …
最常突变的基因是H3 F3A、PHF 6、ATRx、KDM 6A、SMARCA 4、ASXL 2、CREBBP、EZH 2、MLL 2、USP 7、ASXL 1、NSD 2、SET 2、SMC 1A和ZMYM 3。...总的来说，我们的结果有助于定义儿科癌症中表观遗传调节基因突变的格局.
The most frequently mutated genes are H3F3A, PHF6, ATRX, KDM6A, SMARCA4, ASXL2, CREBBP, EZH2, MLL2, USP7, ASXL1, NSD2, SETD2, SMC1A a …
Structural and functional insights into the human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6. The Journal of Biological Chemistry生物学TOPEI检索SCI升级版 生物学2区SCI基础版 生物2区IF 4.0
人类Borjeson-Forssman-Lehmann综合征相关蛋白PHF 6的结构和功能见解。The Journal of Biological Chemistry生物学TOPe检查SCI升级版生物学2区SCI基础版生物2区IF 4.0
Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J, Shi Y. Liu Z, et al. J Biol Chem. 2014 Apr 4;289(14):10069-83. doi: 10.1074/jbc.M113.535351. Epub 2014 Feb 19. J Biol Chem. 2014. PMID: 24554700 Free PMC article.
PHF6-ePHD2 appears to fold as a novel integrated structural module. Structural analysis of PHF6-ePHD2 reveals pathological implication of PHF6 gene mutations in Borjeson-Forssman-Lehmann syndrome, T-cell acute lymphoblastic leukemia, and acute myeloid leukemi …
PHF6-ePHD2似乎作为一种新型的集成结构模块而折叠。结构分析揭示了Borjeson-Forssman-Lehmann综合征、T细胞急性淋巴细胞白血病和急性髓系白血病…中PHF6基因突变的病理学意义
PHF6-ePHD2 appears to fold as a novel integrated structural module. Structural analysis of PHF6-ePHD2 reveals pathological imp …
Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL. Cancer InformaticsIF 2.4
儿童B-ALL种族内和种族间基因表达变异模式分析癌症信息学IF 2.4
Hicks C, Miele L, Koganti T, Young-Gaylor L, Rogers D, Vijayakumar V, Megason G. Hicks C, et al. Cancer Inform. 2013 Aug 27;12:155-73. doi: 10.4137/CIN.S11831. eCollection 2013. Cancer Inform. 2013. PMID: 24023509 Free PMC article.

B-Precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Although 80% of B-ALL patients are able to be cured, significant challenges persist. ...We identified 300 highly significantly (P < 0.001) differentially expressed genes between the fo
B前体急性淋巴细胞白血病(B-ALL)是儿童最常见的癌症。尽管80%的B-ALL患者能够治愈，但重大挑战依然存在。我们共鉴定出300个差异显著(P<0.001)的基因.

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B-Precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Although 80% of B-ALL patients are able to be c …
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. The Journal of Biological Chemistry生物学TOPEI检索SCI升级版 生物学2区SCI基础版 生物2区IF 4.0
PHF6通过抑制核糖体RNA的合成来调节细胞周期进程。《生物化学杂志》生物学TOPEI检索SCI升级版生物学2区SCI基础版生物2区IF 4.0
Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. Wang J, et al. J Biol Chem. 2013 Feb 1;288(5):3174-83. doi: 10.1074/jbc.M112.414839. Epub 2012 Dec 10. J Biol Chem. 2013. PMID: 23229552 Free PMC article.
However, it remains to be determined exactly how PHF6 acts in vivo and what functions of PHF6 may be associated with its putative tumor suppressor function. ...Together, these results reveal that the key function of PHF6 is involved in regulating rRNA …
然而，PHF6在体内的确切作用以及PHF6的哪些功能可能与其假定的肿瘤抑制功能相关仍有待确定。综上所述，这些结果表明，PHF6的关键功能参与了调节rRNARNA的….
However, it remains to be determined exactly how PHF6 acts in vivo and what functions of PHF6 may be associated with its putat …
High accuracy mutation detection in leukemia on a selected panel of cancer genes. Plos OneSCI升级版 综合性期刊3区SCI基础版 综合性期刊3区IF 2.9
在选定的一组癌症基因上进行白血病的高精度突变检测。PLOS OneSCI升级版综合性期刊3区SCI基础版综合性期刊3区IF 2.9
Kalender Atak Z, De Keersmaecker K, Gianfelici V, Geerdens E, Vandepoel R, Pauwels D, Porcu M, Lahortiga I, Brys V, Dirks WG, Quentmeier H, Cloos J, Cuppens H, Uyttebroeck A, Vandenberghe P, Cools J, Aerts S. Kalender Atak Z, et al. PLoS One. 2012;7(6):e38463. doi: 10.1371/journal.pone.0038463. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675565 Free PMC article.
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming available for many cancer types. Increasing access to sequencing technology, including bench-top sequencers, provide the opportunity to …
随着全基因组和全外显子组测序的出现，高质量的重复突变的癌症基因目录正变得适用于许多癌症类型。越来越多的人获得测序技术，包括台式测序仪，这为…提供了机会
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming av …
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. New England Journal of Medicine医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 96.2
急性粒细胞白血病综合遗传分析的预后相关性。新英格兰医学杂志TOPSCI升级版医学1区SCI基础版医学1区IF 96.2
Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S, Aminova O, Huberman K, Cheng J, Viale A, Socci ND, Heguy A, Cherry A, Vance G, Higgins RR, Ketterling RP, Gallagher RE, Litzow M, van den Brink MR, Lazarus HM, Rowe JM, Luger S, Ferrando A, Paietta E, Tallman MS, Melnick A, Abdel-Wahab O, Levine RL. Patel JP, et al. N Engl J Med. 2012 Mar 22;366(12):1079-89. doi: 10.1056/NEJMoa1112304. Epub 2012 Mar 14. N Engl J Med. 2012. PMID: 22417203 Free PMC article.
We found that internal tandem duplication in FLT3 (FLT3-ITD), partial tandem duplication in MLL (MLL-PTD), and mutations in ASXL1 and PHF6 were associated with reduced overall survival (P=0.001 for FLT3-ITD, P=0.009 for MLL-PTD, P=0.05 for ASXL1, and P=0.006 for PHF6 …
我们发现FLT 3的内部串联重复（FLT 3-ITD）、MLL的部分串联重复（MLL-PTD）以及ASXL 1和PHF 6的突变与总生存率下降有关（FLT 3-ITD P=0.001，MLL-PTD P =0.009，ASXL 1 P=0.05，PHF 6 P=0.006.
We found that internal tandem duplication in FLT3 (FLT3-ITD), partial tandem duplication in MLL (MLL-PTD), and mutations in ASXL1 and PHF …
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 31.7
急性T细胞淋巴细胞白血病（T-ALL）中的合作微RNA-肿瘤抑制基因网络。Nature Genetics生物学TOPSCI升级版生物学1区SCI基础版生物1区IF 31.7
Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG. Mavrakis KJ, et al. Nat Genet. 2011 Jun 5;43(7):673-8. doi: 10.1038/ng.858. Nat Genet. 2011. PMID: 21642990 Free PMC article.
Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action …
此外，这些miRNA对参与T-ALL发病机制的肿瘤抑制基因产生重叠和协同作用，包括IKAROS（也称为IKZR 1）、PEN、MBE、PHF 6、NF 1和FBXW 7。因此，对mRNA作用进行全面、公正的分析..
Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, …
PHF6 mutations in adult acute myeloid leukemia. Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 12.8
成人急性粒细胞白血病中的PHF 6突变。Leukemia医学TOPSCI升级版医学1区SCI基础版医学1区IF 12.8
Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, Cools J, Levine R, Ferrando A. Van Vlierberghe P, et al. Leukemia. 2011 Jan;25(1):130-4. doi: 10.1038/leu.2010.247. Epub 2010 Oct 29. Leukemia. 2011. PMID: 21030981 Free PMC article.
As in the case of T-ALL, where PHF6 alterations are found almost exclusively in males, mutations in PHF6 were seven times more prevalent in males than in females with AML. Overall, these results identify PHF6 as a tumor suppressor gene mutated in AML a …
与T-ALL的情况一样，PHF 6突变几乎只在男性中发现，男性中PHF 6突变的患病率是女性中的七倍。总体而言，这些结果将PHF 6确定为在急性白血病和..
As in the case of T-ALL, where PHF6 alterations are found almost exclusively in males, mutations in PHF6 were seven times more …
T-cell acute lymphoblastic leukemia in association with Borjeson-Forssman-Lehmann syndrome due to a mutation in PHF6. Pediatric Blood & CancerSCI升级版 医学3区SCI基础版 医学3区IF 2.4
PHF 6突变导致T细胞急性淋巴细胞白血病与Borjeson-Forssman-Lehmann综合征相关。Pediatric Blood & CancerSCI升级版医学3区SCI基础版医学3区IF 2.4
Chao MM, Todd MA, Kontny U, Neas K, Sullivan MJ, Hunter AG, Picketts DJ, Kratz CP. Chao MM, et al. Pediatr Blood Cancer. 2010 Oct;55(4):722-4. doi: 10.1002/pbc.22574. Pediatr Blood Cancer. 2010. PMID: 20806366 Free PMC article.
The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T-cell lymphomas. Our observation indicates that BFLS may repr …
PHF 6基因位于X染色体上，编码具有两个PHD型锌指结构域和四个核定位序列的蛋白质。此前，在小鼠T细胞淋巴瘤中观察到Phf 6的过度表达。我们的观察表明BFLS可能代表.
The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localizatio …
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PHF6 mutations in T-cell acute lymphoblastic leukemia.
T细胞急性淋巴细胞白血病中的PHF 6突变。 Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 31.7
Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A. Van Vlierberghe P, et al. Nat Genet. 2010 Apr;42(4):338-42. doi: 10.1038/ng.542. Epub 2010 Mar 14. Nat Genet. 2010. PMID: 20228800 Free PMC article.
Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. ...Overall, these results identify PHF6 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between PHF6 l …
X染色体上的肿瘤抑制基因可能会扭曲特定类型癌症的性别分布。...总体而言，这些结果将PHF 6确定为T-ALL中一种新的X连锁肿瘤抑制因子，并指出PHF 6与..
Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. ...Overall, these res …
Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene.
辐射白血病病毒在Kis2位点的共同整合：一个新的非编码RNA和近端Phf6基因的同时过表达。 Journal of Virology医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 4.0
Landais S, Quantin R, Rassart E. Landais S, et al. J Virol. 2005 Sep;79(17):11443-56. doi: 10.1128/JVI.79.17.11443-11456.2005. J Virol. 2005. PMID: 16103195 Free PMC article.
Retroviral tagging has been used extensively and successfully to identify genes implicated in cancer pathways. In order to find oncogenes implicated in T-cell leukemia, we used the highly leukemogenic radiation leukemia retrovirus VL3 (RadLV/VL3). ...In this article, we re …
逆转录病毒标签已被广泛且成功地用于识别与癌症途径有关的基因。为了寻找与T细胞白血病有关的癌基因，我们使用了高致白血病性放射性白血病逆转录病毒VL 3（RadLV/VL 3）。...在本文中，我们重新.
Retroviral tagging has been used extensively and successfully to identify genes implicated in cancer pathways. In order to find oncog …
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