Started onMonday, 2 December 2024, 2:22 PM
StateFinished
Completed onMonday, 2 December 2024, 2:33 PM
Time taken11 mins 6 secs
Grade9.00 out of 10.00 (90%)

Question 1

Complete
Mark 1.00 out of 1.00

Question text

Based on your observations in “Factors influencing dissolution” laboratory practical, which of the following definitions best describes dissolution?


Question 1 Answer
a.

The rate at which a drug forms a suspension


b.

The quantity of drug that will dissolve in 500 mL of dissolution media within 45 minutes


c.

The maximum quantity of drug that dissolves in a given volume of solvent


d.

The rate at which a drug forms a solution


e.

The quantity of drug that will dissolve in 900 mL of dissolution media within 30 minutes


Question 2

Complete
Mark 1.00 out of 1.00

Question text

Based on the experiments that you performed in Lab practical 4, an increase in which of the following factors is a practical way of increasing drug Diffusivity (D = RT/6rNη):


Question 2 Answer
a.

Molecular radius


b.

Viscosity


c.

Avogadro’s constant


d.

Temperature


e.

Gas constant


Question 3

Complete
Mark 1.00 out of 1.00

Question text

What is the expected effect of increasing the temperature of the solvent on dissolution of sodium chloride?


Question 3 Answer
a.

High temperature increases the dissolution rate

b.

High temperature decreases the solubility of sodium chloride


c.

High temperature decreases the dissolution rate


d.

High temperature increase the solubility of sodium chloride


e.

High temperature has no effect on the dissolution rate


Question 4

Complete
Mark 1.00 out of 1.00

Question text

You are tasked with creating a fast acting drug formulation. A focus of this development is optimisation of the dissolution. As part of this development a number of particle engineering strategies have led to drug particles of different  size (in microns). Which of the following particle sizes would you expect to have the fastest dissolution?


Question 4 Answer
a.

1.5 ± 0.3 micron


b.

2.5 ± 0.4 micron


c.

2.1 ± 0.2 micron

d.

5.5 ± 0.3 micron

e.

3.8 ± 0.1 micron


Question 5

Complete
Mark 1.00 out of 1.00

Question text

In the laboratory, you evaluated the effect of agitation on the dissolution rate. In pharmaceutical R&D, dissolution experiments are typically performed using automated Dissolution Apparatus. The degree of agitation in Dissolution apparatus is controlled by an electronic rotor and is measured in revolutions per minute (rpm). In general, the higher the rpm the greater the agitation. Which of the following rotor speeds would you expect to yield the fastest dissolution?


Question 5 Answer
a.

25 rpm


b.

50 rpm

c.

75 rpm


d.

10 rpm


e.

65 rpm

Question 6

Complete
Mark 1.00 out of 1.00

Question text

A patient is required to dissolve a tablet in 200 mL of liquid prior to administration. Which of the following liquids would you expect the fastest dissolution?


Question 6 Answer
a.

Water (viscosity: 1 cP)


b.

Orange juice (viscosity: 48 cP)


c.

Tomato Juice (viscosity: 300 cP)

d.

Milk (viscosity: 3 cP)


e.

Honey (viscosity: 2000-10000 cP)


Question 7

Complete
Mark 1.00 out of 1.00

Question text

The dissolution time (s) of NaCl (0.5g) increases when there is a concurrent increase in the concentration of NaCl that is already in solution. This physical behaviour relates to which factor in the Noyes Whitney Equation?


Question 7 Answer
a.

Concentration difference


b.

Particle size


c.

Degree of agitation


d.

Temperature


e.

Solubility


Question 8

Complete
Mark 1.00 out of 1.00

Question text

Which of the following drugs would you expect to have the greatest dissolution? (Note the unit difference: mcg refers to microgram, mg refers to miligram)


Question 8 Answer
a.

Aspirin (Cs: 3 mg/mL)


b.

Codeine (Cs: 1 mg/mL)


c.

Ibuprofen (Cs: 21 mcg/mL)


d.

Paracetamol (Cs: 14 mg/mL)


e.

Naproxen (Cs: 16 mcg/mL)


Question 9

Complete
Mark 1.00 out of 1.00

Question text

You add 1 g of a compound to 100 mL of water. Which of the following observations would lead you to believe that the compound was completely dissolved?


Question 9 Answer
a.

Formation of a fine heterogenous particulate dispersion


b.

Formation of a coarse dispersion that exhibits kinetic stability


c.

Formation of a clear homogenous dispersion


d.

Formation of a coarse dispersion that sediments after 15 minutes


e.

Formation of a settled heterogenous dispersion

Question 10

Complete
Mark 0.00 out of 1.00

Question text

Which of the following steps is considered an effective way of reducing the thickness of the thickness of the diffusion layer (δ) that surrounds drug particles during dissolution?

Diffusion layer of particle


Question 10 Answer
a.

Decrease viscosity of the dissolution media


b.

Increase the molecular radius of the dissolving species

c.

Increase the particle size


d.

Decrease the temperature


e.

Increase the extent of mixing

Finish review