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Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
急性髓系白血病整合基因图谱的预后相关性。 New England Journal of Medicine医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 158.5
Patel JP, Gönen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, Van Vlierberghe P, Dolgalev I, Thomas S, Aminova O, Huberman K, Cheng J, Viale A, Socci ND, Heguy A, Cherry A, Vance G, Higgins RR, Ketterling RP, Gallagher RE, Litzow M, van den Brink MR, Lazarus HM, Rowe JM, Luger S, Ferrando A, Paietta E, Tallman MS, Melnick A, Abdel-Wahab O, Levine RL. Patel JP, et al. N Engl J Med. 2012 Mar 22;366(12):1079-89. doi: 10.1056/NEJMoa1112304. Epub 2012 Mar 14. N Engl J Med. 2012. PMID: 22417203 Free PMC article.
We found that internal tandem duplication in FLT3 (FLT3-ITD), partial tandem duplication in MLL (MLL-PTD), and mutations in ASXL1 and PHF6 were associated with reduced overall survival (P=0.001 for FLT3-ITD, P=0.009 for MLL-PTD, P=0.05 for ASXL1, and P=0.006 for PHF6 …
我们发现FLT 3的内部串联重复（FLT 3-ITD）、MLL的部分串联重复（MLL-PTD）以及ASXL 1和PHF 6的突变与总生存率降低相关（FLT 3-ITD P=0.001，MLL-PTD P =0.009，ASXL 1 P=0.05，PHF 6 P=0.006）。
We found that internal tandem duplication in FLT3 (FLT3-ITD), partial tandem duplication in MLL (MLL-PTD), and mutations in ASXL1 and PHF …
PHF6 recruits BPTF to promote HIF-dependent pathway and progression in YAP-high breast cancer.
PHF 6募集BPTF以促进HIF依赖性途径和YAP高乳腺癌的进展 Journal of Translational Medicine医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 7.4
Gao S, Zhang W, Ma J, Ni X. Gao S, et al. J Transl Med. 2023 Mar 26;21(1):220. doi: 10.1186/s12967-023-04031-8. J Transl Med. 2023. PMID: 36967443 Free PMC article.
PHF6 promotes Bca proliferation and migration. By analyzing The Cancer Genome Atlas breast cancer (TCGA-Bca) cohort, we found that PHF6 was significantly higher in tumor versus normal tissues. ...HIF-DKO abolished PHF6-mediated breast …
PHF 6促进Bca增殖和迁移。通过分析癌症基因组图谱乳腺癌（TCGA-Bca）队列，我们发现PHF 6在肿瘤中的表达显著高于正常组织。... HIF-DKO阻断了PHF 6介导的乳腺癌细胞凋亡。
PHF6 promotes Bca proliferation and migration. By analyzing The Cancer Genome Atlas breast cancer (TCGA-Bca) cohort, we …
PHF6 Mutations in Hematologic Malignancies.
血液肿瘤中的PHF 6突变。 Frontiers in OncologySCI升级版 医学3区SCI基础版 医学2区IF 4.7
Kurzer JH, Weinberg OK. Kurzer JH, et al. Front Oncol. 2021 Jul 26;11:704471. doi: 10.3389/fonc.2021.704471. eCollection 2021. Front Oncol. 2021. PMID: 34381727 Free PMC article. Review.
PHF6 serves as a tumor suppressor protein, with PHF6 mutations and deletions often implicated in the development of T-lymphoblastic leukemia and less frequently in acute myeloid leukemia and other myeloid neoplasms. ...Due to conflicting data, the prognostic …
PHF 6作为一种肿瘤抑制蛋白，PHF 6突变和缺失通常与T淋巴细胞白血病的发展有关，而在急性髓性白血病和其他髓性肿瘤中不太常见。...由于数据不一致，预测...
PHF6 serves as a tumor suppressor protein, with PHF6 mutations and deletions often implicated in the development of T-l …
The Role of PHF6 in Hematopoiesis and Hematologic Malignancies.
PHF 6在造血和血液肿瘤中的作用 Stem Cell Reviews And ReportsSCI升级版 医学3区SCI基础版 医学2区IF 4.8
Eisa YA, Guo Y, Yang FC. Eisa YA, et al. Stem Cell Rev Rep. 2023 Jan;19(1):67-75. doi: 10.1007/s12015-022-10447-4. Epub 2022 Aug 26. Stem Cell Rev Rep. 2023. PMID: 36008597 Review.
These data demonstrate that PHF6 could act as a double-edged sword, either a tumor suppressor or an oncogene, in a lineage-dependent manner. ...In this review, we summarize current knowledge of PHF6, emphasizing the role of PHF6 in hematological malign …
这些数据表明，PHF 6可以作为一把双刃剑，无论是肿瘤抑制基因或癌基因，在一个谱系依赖的方式。...本文就PHF 6的研究进展作一综述，强调PHF 6在血液系统恶性肿瘤中的作用。
These data demonstrate that PHF6 could act as a double-edged sword, either a tumor suppressor or an oncogene, in a lineage-dep …
PHF6 functions as a tumor suppressor by recruiting methyltransferase SUV39H1 to nucleolar region and offers a novel therapeutic target for PHF6-muntant leukemia.
PHF6通过将甲基转移酶SUV39H1募集到核仁区而发挥抑癌作用，为PHF6突变型白血病提供了一个新的治疗靶点。 Acta Pharmaceutica Sinica b医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 14.5
Tsai HI, Wu Y, Huang R, Su D, Wu Y, Liu X, Wang L, Xu Z, Pang Y, Sun C, He C, Shu F, Zhu H, Wang D, Cheng F, Huang L, Chen H. Tsai HI, et al. Acta Pharm Sin B. 2022 Apr;12(4):1913-1927. doi: 10.1016/j.apsb.2021.10.025. Epub 2021 Oct 30. Acta Pharm Sin B. 2022. PMID: 35847518 Free PMC article.
The knockdown of either SUV39H1 or PHF6 significantly attenuated the effects of increase in H3K9me3 and suppressed the transcription of rDNA induced by the overexpression of the other interacting partner, thereby establishing an interdependent relationship between PHF6 …
SUV39H1或PHF6的敲低显著减弱了H3K9me3增加的影响，并抑制了由另一个相互作用伴侣的过表达诱导的rDNA转录，从而建立了PHF6和H3K9me3之间的相互依赖关系。
The knockdown of either SUV39H1 or PHF6 significantly attenuated the effects of increase in H3K9me3 and suppressed the transcription …
PHF6 maintains acute myeloid leukemia via regulating NF-kappaB signaling pathway.
PHF 6通过调节NF-κ B信号通路维持急性髓系白血病的发生。 Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 11.4
Hou S, Wang X, Guo T, Lan Y, Yuan S, Yang S, Zhao F, Fang A, Liu N, Yang W, Chu Y, Jiang E, Cheng T, Sun X, Yuan W. Hou S, et al. Leukemia. 2023 Aug;37(8):1626-1637. doi: 10.1038/s41375-023-01953-6. Epub 2023 Jul 1. Leukemia. 2023. PMID: 37393343 Free PMC article.
PHF6 depletion inhibited the NF-kappaB signaling pathways by disrupting the PHF6-p50 complex and partially inhibiting the nuclear translocation of p50 to suppress the expression of BCL2. ...Taken together, in contrast to PHF6 as a tumor suppressor in T …
PHF 6耗竭通过破坏PHF 6-p50复合物和部分抑制p50的核转位来抑制BCL 2的表达，从而抑制NF-κ B信号通路。...总之，与PHF 6作为T细胞中的肿瘤抑制因子相比，PHF 6在T细胞中的作用更强。
PHF6 depletion inhibited the NF-kappaB signaling pathways by disrupting the PHF6-p50 complex and partially inhibiting the nucl …
Phf6 Loss Enhances HSC Self-Renewal Driving Tumor Initiation and Leukemia Stem Cell Activity in T-ALL.
Phf 6缺失增强T-ALL中HSC自我更新驱动肿瘤起始和白血病干细胞活性 Cancer Discovery医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 29.1
Wendorff AA, Quinn SA, Rashkovan M, Madubata CJ, Ambesi-Impiombato A, Litzow MR, Tallman MS, Paietta E, Paganin M, Basso G, Gastier-Foster JM, Loh ML, Rabadan R, Van Vlierberghe P, Ferrando AA. Wendorff AA, et al. Cancer Discov. 2019 Mar;9(3):436-451. doi: 10.1158/2159-8290.CD-18-1005. Epub 2018 Dec 19. Cancer Discov. 2019. PMID: 30567843 Free PMC article.
Consistent with a leukemia-initiating tumor suppressor role, inactivation of Phf6 in hematopoietic progenitors lowers the threshold for the development of NOTCH1-induced T-ALL. ...These results implicate Phf6 in the control of HSC homeostasis and long-term se …
与白血病启动肿瘤抑制作用一致，造血祖细胞中Phf 6的失活降低了NOTCH 1诱导的T-ALL发展的阈值。...这些结果暗示Phf 6在HSC的稳态和长期稳定的控制。
Consistent with a leukemia-initiating tumor suppressor role, inactivation of Phf6 in hematopoietic progenitors lowers the thre …
LINC00958/miR-3174/PHF6 axis is responsible for triggering proliferation, migration and invasion of endometrial cancer.
LINC 00958/miR-3174/PHF 6轴负责触发子宫内膜癌的增殖、迁移和侵袭。 European Review For Medical And Pharmacological SciencesSCI升级版 医学4区SCI基础版 医学3区IF 3.3
Li QY, Shen JQ, Li JH, Dai DF, Saeed M, Li CX. Li QY, et al. Eur Rev Med Pharmacol Sci. 2021 Nov;25(22):6853-6861. doi: 10.26355/eurrev_202111_27233. Eur Rev Med Pharmacol Sci. 2021. PMID: 34859848 Free article.
Dual-Luciferase reporter assay was carried out to identify the LINC00958/miR-3174/PHF6 axis, and their expression interaction was determined by Pearson correlation test. ...It stimulates EC to proliferate, migrate and invade through the miR-3174/PHF6 axis....
采用双荧光素酶报告基因分析法鉴定LINC 00958/miR-3174/PHF 6轴，Pearson相关性检验确定其表达相互作用。...它通过miR-3174/PHF 6轴刺激EC增殖、迁移和侵袭。
Dual-Luciferase reporter assay was carried out to identify the LINC00958/miR-3174/PHF6 axis, and their expression interaction was det …
PHF6 promotes the progression of endometrial carcinoma by increasing cancer cells growth and decreasing T-cell infiltration.
PHF 6通过增加癌细胞生长和减少T细胞浸润促进子宫内膜癌的进展。 Journal of Cellular And Molecular Medicine医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 5.3
Wang X, Fang A, Peng Y, Yu J, Yu C, Xie J, Zheng Y, Song L, Li P, Li J, Kang X, Lin Y, Li W. Wang X, et al. J Cell Mol Med. 2023 Mar;27(5):609-621. doi: 10.1111/jcmm.17638. Epub 2023 Feb 8. J Cell Mol Med. 2023. PMID: 36756714 Free PMC article.
The UCEC patients with high PHF6 expression had poor survival than UCEC patients with low PHF6 expression. PHF6 mutation occurred in 12% of UCEC patients, and PHF6 mutation predicted favourable clinical outcome in UCEC patients. ...
PHF 6高表达的UCEC患者的生存率低于PHF 6低表达的UCEC患者。12%的UCEC患者发生PHF 6突变，PHF 6突变预测UCEC患者的良好临床结局。...
The UCEC patients with high PHF6 expression had poor survival than UCEC patients with low PHF6 expression. PHF6 mutatio …
Next-Generation Sequencing-Based Genomic Profiling of Children with Acute Myeloid Leukemia.
下一代基于测序的儿童急性髓性白血病基因组分析。 Journal of Molecular DiagnosticsSCI升级版 医学3区SCI基础版 医学2区IF 4.1
Krizsán S, Péterffy B, Egyed B, Nagy T, Sebestyén E, Hegyi LL, Jakab Z, Erdélyi DJ, Müller J, Péter G, Csanádi K, Kállay K, Kriván G, Barna G, Bedics G, Haltrich I, Ottóffy G, Csernus K, Vojcek Á, Tiszlavicz LG, Gábor KM, Kelemen Á, Hauser P, Gaál Z, Szegedi I, Ujfalusi A, Kajtár B, Kiss C, Matolcsy A, Tímár B, Kovács G, Alpár D, Bödör C. Krizsán S, et al. J Mol Diagn. 2023 Aug;25(8):555-568. doi: 10.1016/j.jmoldx.2023.04.004. Epub 2023 Apr 22. J Mol Diagn. 2023. PMID: 37088137 Free PMC article.
Our study identified novel recurrent mutations at diagnosis in the BCORL1 gene in 9% of the patients. Tumor suppressor gene (PHF6, TP53, and WT1) mutations were found to be associated with induction failure and shorter event-free survival, suggesting important roles …
我们的研究在9%的患者中发现了BCORL 1基因诊断时的新复发突变。肿瘤抑制基因（PHF 6，TP 53和WT 1）突变被发现与诱导失败和较短的无事件生存期相关，表明肿瘤抑制基因在诱导失败中的重要作用。
Our study identified novel recurrent mutations at diagnosis in the BCORL1 gene in 9% of the patients. Tumor suppressor gene (PHF6 …
The potential role of PHF6 as an oncogene: a genotranscriptomic/proteomic meta-analysis.
PHF 6作为癌基因的潜在作用：基因转录组学/蛋白质组学荟萃分析 Tumour Biology : The Journal of The International Society For Oncodevelopmental Biology And Medicine
肿瘤生物学：国际肿瘤发育生物学与医学学会杂志
Hajjari M, Salavaty A, Crea F, Kee Shin Y. Hajjari M, et al. Tumour Biol. 2016 Apr;37(4):5317-25. doi: 10.1007/s13277-015-4250-0. Epub 2015 Nov 11. Tumour Biol. 2016. PMID: 26561469
Notably, PHF6 was under-expressed in a few types of cancer, including esophageal tumors. ...Our results suggest that PHF6 may function as an oncogenic factor in several types of cancer. ...
值得注意的是，PHF 6在一些类型的癌症中表达不足，包括食管肿瘤。...我们的研究结果表明，PHF 6可能作为一个致癌因子在几种类型的癌症。...
Notably, PHF6 was under-expressed in a few types of cancer, including esophageal tumors. ...Our results suggest that PHF6 …
Downregulation of PHF6 Inhibits Cell Proliferation and Migration in Hepatocellular Carcinoma.
PHF 6下调抑制肝癌细胞增殖和迁移 Cancer Biotherapy And RadiopharmaceuticalsSCI升级版 医学4区SCI基础版 医学4区IF 3.4
癌症生物治疗和放射性药物SCI升级版医学4区SCI基础版医学4区IF 3.4
Yu Q, Yin L, Jian Y, Li P, Zeng W, Zhou J. Yu Q, et al. Cancer Biother Radiopharm. 2019 May;34(4):245-251. doi: 10.1089/cbr.2018.2671. Epub 2019 Mar 19. Cancer Biother Radiopharm. 2019. PMID: 30888215
Background: The plant homeodomain finger 6 (PHF6) was originally identified as single gene mutated in Borjeson-Forssman-Lehmann syndrome, which was reported to be a tumor suppressor in T-cell acute lymphoblastic leukemia. ...Conclusions: These findings suggest that …
背景资料：植物同源结构域指6（PHF 6）最初被鉴定为Borjeson-Forssman-Lehmann综合征中的单基因突变，据报道其是T细胞急性淋巴细胞白血病的肿瘤抑制因子。...结论：这些发现表明，…
Background: The plant homeodomain finger 6 (PHF6) was originally identified as single gene mutated in Borjeson-Forssman-Lehmann syndr …
Context-specific tumor suppression by PHF6.
PHF6的背景特异性肿瘤抑制。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 20.3
Trowbridge JJ. Trowbridge JJ. Blood. 2019 Apr 18;133(16):1698-1700. doi: 10.1182/blood-2019-03-900829. Blood. 2019. PMID: 31000514 Free PMC article.
In this issue of Blood, McRae et al report that loss of plant homeodomain finger 6 (Phf6) increases the ability of hematopoietic stem and progenitor cells (HSPCs) to sustain long-term engraftment and can specifically synergize with the oncogenic homeobox transcription fact …
在这一期的血液中，麦克雷等人报告说，植物同源结构域指6（Phf 6）的缺失增加了造血干细胞和祖细胞（HSPC）维持长期植入的能力，并可以特异性地与致癌同源框转录因子协同作用。
In this issue of Blood, McRae et al report that loss of plant homeodomain finger 6 (Phf6) increases the ability of hematopoietic stem …
Chromatin regulators and their impact on DNA repair and G2 checkpoint recovery.
染色质调节剂及其对DNA修复和G2检查点恢复的影响。 Cell CycleSCI升级版 生物学3区SCI基础版 生物3区IF 4.3
Smits VAJ, Alonso-de Vega I, Warmerdam DO. Smits VAJ, et al. Cell Cycle. 2020 Sep;19(17):2083-2093. doi: 10.1080/15384101.2020.1796037. Epub 2020 Jul 30. Cell Cycle. 2020. PMID: 32730133 Free PMC article. Review.
We recently performed a reverse genetic screen for novel chromatin regulators that control checkpoint recovery after DNA damage. Here we discuss the implications of PHD finger protein 6 (PHF6) and additional candidates from the NuA4 ATPase-dependent chromatin-remodeling co …
我们最近进行了一项反向遗传筛选，以寻找控制DNA损伤后检查点恢复的新型染色质调节因子。在这里，我们讨论了PHD指蛋白6（PHF6）和其他候选人从NuA4 ATP酶依赖的染色质重塑的影响。
We recently performed a reverse genetic screen for novel chromatin regulators that control checkpoint recovery after DNA damage. Here we dis …
The co-regulatory networks of tumor suppressor genes, oncogenes, and miRNAs in colorectal cancer.
结直肠癌中肿瘤抑制基因、癌基因和miRNAs的共同调控网络。 Genes Chromosomes & CancerSCI升级版 医学2区SCI基础版 医学3区IF 3.7
Slattery ML, Herrick JS, Mullany LE, Samowitz WS, Sevens JR, Sakoda L, Wolff RK. Slattery ML, et al. Genes Chromosomes Cancer. 2017 Nov;56(11):769-787. doi: 10.1002/gcc.22481. Epub 2017 Jul 30. Genes Chromosomes Cancer. 2017. PMID: 28675510 Free PMC article.
Tumor suppressor genes (TSGs) and oncogenes (OG) are involved in carcinogenesis. MiRNAs also contribute to cellular pathways leading to cancer. We use data from 217 colorectal cancer (CRC) cases to evaluate differences in TSGs and OGs expression between paire …
肿瘤抑制基因（TSGs）和癌基因（OG）参与了肿瘤的发生。miRNAs也有助于导致癌症的细胞途径。我们使用来自217例结直肠癌（CRC）病例的数据来评估TSGs和OGs表达在结直肠癌患者中的差异。
Tumor suppressor genes (TSGs) and oncogenes (OG) are involved in carcinogenesis. MiRNAs also contribute to cellular pathways leading …
PHF6 regulates hematopoietic stem and progenitor cells and its loss synergizes with expression of TLX3 to cause leukemia.
PHF6调节造血干细胞和祖细胞，其缺失与TLX3的表达协同作用导致白血病。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 20.3
McRae HM, Garnham AL, Hu Y, Witkowski MT, Corbett MA, Dixon MP, May RE, Sheikh BN, Chiang W, Kueh AJ, Nguyen TA, Man K, Gloury R, Aubrey BJ, Policheni A, Di Rago L, Alexander WS, Gray DHD, Strasser A, Hawkins ED, Wilcox S, Gécz J, Kallies A, McCormack MP, Smyth GK, Voss AK, Thomas T. McRae HM, et al. Blood. 2019 Apr 18;133(16):1729-1741. doi: 10.1182/blood-2018-07-860726. Epub 2019 Feb 12. Blood. 2019. PMID: 30755422 Free PMC article.
Loss of PHF6 caused increased and sustained hematopoietic reconstitution in serial transplantation experiments. ...Ectopic expression of TLX3 alone caused partially penetrant leukemia. TLX3 expression and loss of PHF6 combined caused fully penetrant early-onset leuk …
PHF6的缺失导致系列移植实验中造血重建的增加和持续。... TLX3的异位表达单独引起部分渗透性白血病。TLX3的表达和PHF 6的缺失共同导致了完全穿透的早发性勒克。
Loss of PHF6 caused increased and sustained hematopoietic reconstitution in serial transplantation experiments. ...Ectopic expression …
The chromatin-binding protein Phf6 restricts the self-renewal of hematopoietic stem cells.
染色质结合蛋白Phf 6限制造血干细胞的自我更新。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 20.3
Miyagi S, Sroczynska P, Kato Y, Nakajima-Takagi Y, Oshima M, Rizq O, Takayama N, Saraya A, Mizuno S, Sugiyama F, Takahashi S, Matsuzaki Y, Christensen J, Helin K, Iwama A. Miyagi S, et al. Blood. 2019 Jun 6;133(23):2495-2506. doi: 10.1182/blood.2019000468. Epub 2019 Mar 27. Blood. 2019. PMID: 30917958 Free article.
However, the role of PHF6 in normal hematopoiesis and its tumor-suppressor function remain largely unknown. ...Mechanistically, Phf6 directly and indirectly activated downstream effectors in tumor necrosis factor alpha (TNFalpha) signaling. ...
然而，PHF 6在正常造血中的作用及其肿瘤抑制功能在很大程度上仍然未知。...在机制上，Phf6直接和间接激活肿瘤坏死因子α（TNF α）信号传导中的下游效应物。...
However, the role of PHF6 in normal hematopoiesis and its tumor-suppressor function remain largely unknown. ...Mechanistically …
Genomic landscape of T-cell lymphoblastic lymphoma.
T细胞淋巴母细胞淋巴瘤的基因组景观。 Chinese Journal of Cancer ResearchSCI升级版 医学2区SCI基础版 医学2区IF 5.1
Li Z, Song Y, Zhang M, Wei Y, Ruan H. Li Z, et al. Chin J Cancer Res. 2022 Apr 30;34(2):83-94. doi: 10.21147/j.issn.1000-9604.2022.02.03. Chin J Cancer Res. 2022. PMID: 35685993 Free PMC article.
Notably, besides notch receptor 1 (NOTCH1), mutational status of plant homeodomain (PHD)-like finger protein 6 (PHF6) was identified as another independent factor for good prognosis. Of utmost interest is that co-existence of PHF6 and NOTCH1 mutation status might pr …
值得注意的是，除了notch受体1（NOTCH 1），植物同源结构域（PHD）样指蛋白6（PHF 6）的突变状态被确定为另一个独立的预后良好的因素。最令人感兴趣的是，PHF6和NOTCH1突变状态的共存可能会导致肿瘤的发生。
Notably, besides notch receptor 1 (NOTCH1), mutational status of plant homeodomain (PHD)-like finger protein 6 (PHF6) was identified …
Co-existence of PHF6 and NOTCH1 mutations in adult T-cell acute lymphoblastic leukemia.
成人T细胞急性淋巴细胞白血病中PHF6和NOTCH1突变的共存 Oncology LettersSCI升级版 医学4区SCI基础版 医学4区IF 2.9
Li M, Xiao L, Xu J, Zhang R, Guo J, Olson J, Wu Y, Li J, Song C, Ge Z. Li M, et al. Oncol Lett. 2016 Jul;12(1):16-22. doi: 10.3892/ol.2016.4581. Epub 2016 May 16. Oncol Lett. 2016. PMID: 27347093 Free PMC article.
T-cell acute lymphoblastic leukemia (T-ALL) results from the collaboration of multiple genetic abnormalities in the transformation of T-cell progenitors. Plant homeodomain finger protein 6 (PHF6) has recently been established as a key tumor suppressor, which is muta …
T细胞急性淋巴细胞白血病（T-ALL）是由T细胞祖细胞转化过程中多种遗传异常协同作用的结果。植物同源结构域指状蛋白6（PHF 6）是近年来发现的一种重要的肿瘤抑制因子，它是一种穆塔。
T-cell acute lymphoblastic leukemia (T-ALL) results from the collaboration of multiple genetic abnormalities in the transformation of T-cell …
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis.
PHF6通过抑制核糖体RNA合成来调节细胞周期进程。 The Journal of Biological Chemistry生物学TOPEI检索SCI升级版 生物学2区SCI基础版 生物2区IF 4.8
Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. Wang J, et al. J Biol Chem. 2013 Feb 1;288(5):3174-83. doi: 10.1074/jbc.M112.414839. Epub 2012 Dec 10. J Biol Chem. 2013. PMID: 23229552 Free PMC article.
However, it remains to be determined exactly how PHF6 acts in vivo and what functions of PHF6 may be associated with its putative tumor suppressor function. ...Together, these results reveal that the key function of PHF6 is involved in regulating rRNA …
然而，PHF6在体内的确切作用方式以及PHF6的哪些功能可能与其假定的肿瘤抑制功能相关仍有待确定。...总之，这些结果表明，PHF6的关键功能是参与调节rRNA。
However, it remains to be determined exactly how PHF6 acts in vivo and what functions of PHF6 may be associated with its putat …
Plant homeodomain finger protein 6 in the regulation of normal and malignant hematopoiesis.
植物同源结构域指蛋白6在正常和恶性造血调控中的作用。 Current Opinion in HematologySCI升级版 医学3区SCI基础版 医学3区IF 3.2
Miyagi S, Iwama A. Miyagi S, et al. Curr Opin Hematol. 2020 Jul;27(4):248-253. doi: 10.1097/MOH.0000000000000588. Curr Opin Hematol. 2020. PMID: 32398456 Review.
Mechanistically, Phf6 activates effectors in the tumor necrosis factor alpha (Tnfalpha) pathway. ...Phf6 fulfills a tumor-suppressive function, and its loss synergizes with leukemic lesions to promote the onset of hematological malignancies....
Phf6在机制上激活肿瘤坏死因子α（Tnfalpha）通路中的效应子。... Phf 6具有肿瘤抑制功能，其丢失与白血病病变协同作用，促进血液恶性肿瘤的发生。
Mechanistically, Phf6 activates effectors in the tumor necrosis factor alpha (Tnfalpha) pathway. ...Phf6 fulfills a …
Functional mapping of PHF6 complexes in chromatin remodeling, replication dynamics, and DNA repair.
PHF6复合物在染色质重塑、复制动力学和DNA修复中的功能定位。 Blood医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 20.3
Alvarez S, da Silva Almeida AC, Albero R, Biswas M, Barreto-Galvez A, Gunning TS, Shaikh A, Aparicio T, Wendorff A, Piovan E, Van Vlierberghe P, Gygi S, Gautier J, Madireddy A, A Ferrando A. Alvarez S, et al. Blood. 2022 Jun 9;139(23):3418-3429. doi: 10.1182/blood.2021014103. Blood. 2022. PMID: 35338774 Free PMC article.
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles in transcription regulation. However, specific molecular mechanisms controlled by PHF6 remain rudimentarily understood. Here we show …
植物同源结构域6基因（PHF6）编码一个核仁和染色质相关的白血病肿瘤抑制因子，在转录调控中发挥作用。然而，由PHF6控制的特定分子机制仍然是初步了解的。这里我们展示...
The Plant Homeodomain 6 gene (PHF6) encodes a nucleolar and chromatin-associated leukemia tumor suppressor with proposed roles …
MicroRNA-214 suppresses cell proliferation and migration and cell metabolism by targeting PDK2 and PHF6 in hepatocellular carcinoma.
MicroRNA-214通过靶向PDK 2和PHF 6抑制肝细胞癌中的细胞增殖和迁移以及细胞代谢。 Cell Biology InternationalSCI升级版 生物学3区SCI基础版 生物3区IF 3.9
Yu Q, Zhou J, Jian Y, Xiu Z, Xiang L, Yang D, Zeng W. Yu Q, et al. Cell Biol Int. 2020 Jan;44(1):117-126. doi: 10.1002/cbin.11207. Epub 2019 Aug 19. Cell Biol Int. 2020. PMID: 31329335
Previous studies suggest that pyruvate dehydrogenase kinase 2 (PDK2) and plant homeodomain finger protein 6 (PHF6) may be involved in some tumor cell proliferation and migration. ...Additionally, lactate and pyruvic acid production experiments confirmed miR-214 coul …
以往的研究表明，丙酮酸脱氢酶激酶2（PDK 2）和植物同源结构域指蛋白6（PHF 6）可能参与某些肿瘤细胞的增殖和迁移。...此外，乳酸和维生素A酸的产生实验证实了miR-214可以在细胞内表达。
Previous studies suggest that pyruvate dehydrogenase kinase 2 (PDK2) and plant homeodomain finger protein 6 (PHF6) may be involved in …
Mutations that collaborate with IL-7Ra signaling pathways to drive ALL.
与IL-7 Ra信号通路合作驱动ALL的突变。 Advances in Biological Regulation
生物调控研究进展
Rodrigues GOL, Cramer SD, Winer HY, Hixon JA, Li W, Yunes JA, Durum SK. Rodrigues GOL, et al. Adv Biol Regul. 2021 May;80:100788. doi: 10.1016/j.jbior.2021.100788. Epub 2021 Jan 21. Adv Biol Regul. 2021. PMID: 33578108 Review.
Here we review evidence for additional oncogenic mutations in the IL-7 pathway. We discuss several oncogenes, loss of tumor suppressor genes and epigenetic effects that can cooperate with mutant IL-7 receptor. These include NRas, HOXA, TLX3, Notch 1, Arf, PHF6, WT1, …
在这里，我们审查的IL-7途径中的其他致癌突变的证据。我们讨论了几个癌基因，肿瘤抑制基因的丢失和表观遗传效应，可以与突变型IL-7受体。这些包括NRas、HOXA、TLX 3、Notch 1、Arf、PHF 6、WT 1、.
Here we review evidence for additional oncogenic mutations in the IL-7 pathway. We discuss several oncogenes, loss of tumor suppresso …
Deleterious point mutations in T-cell acute lymphoblastic leukemia: Mechanistic insights into leukemogenesis.
T细胞急性淋巴细胞白血病的有害点突变：白血病发生机制的见解。 International Journal of Cancer医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 6.4
Roy U, Raghavan SC. Roy U, et al. Int J Cancer. 2021 Sep 15;149(6):1210-1220. doi: 10.1002/ijc.33527. Epub 2021 Mar 31. Int J Cancer. 2021. PMID: 33634864 Free article. Review.
Novel oncogenic mutations in the TP53, BRCA2, PTEN, IL7R, RAS, NOTCH1, ETV6, BCL11B, WT1, DNMT3A, PRC2, PHF6, USP7, KDM6A and an array of other genes disrupt the genetic and epigenetic homeostasis in T-ALL. ...
TP 53、BRCA 2、PTEN、IL 7 R、RAS、NOTCH 1、ETV 6、BCL 11 B、WT 1、DNMT 3A、PRC 2、PHF 6、USP 7、KDM 6A和一系列其他基因中的新致癌突变破坏了T-ALL的遗传和表观遗传稳态。...
Novel oncogenic mutations in the TP53, BRCA2, PTEN, IL7R, RAS, NOTCH1, ETV6, BCL11B, WT1, DNMT3A, PRC2, PHF6, USP7, KDM6A and an arra …
MicroRNA-128-3p is a novel oncomiR targeting PHF6 in T-cell acute lymphoblastic leukemia.
MicroRNA-128- 3 p是一种靶向T细胞急性淋巴细胞白血病中PHF 6的新型oncomiR。 Haematologica医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 10.1
Mets E, Van Peer G, Van der Meulen J, Boice M, Taghon T, Goossens S, Mestdagh P, Benoit Y, De Moerloose B, Van Roy N, Poppe B, Vandesompele J, Wendel HG, Van Vlierberghe P, Speleman F, Rondou P. Mets E, et al. Haematologica. 2014 Aug;99(8):1326-33. doi: 10.3324/haematol.2013.099515. Epub 2014 Jun 3. Haematologica. 2014. PMID: 24895337 Free PMC article.
In this context, our previous description of a cooperative microRNA regulatory network controlling several well-known T-cell acute lymphoblastic leukemia tumor suppressor genes, including PHF6, is of great importance. Given the high frequency of PHF6 lesions …
在这种情况下，我们以前描述的合作microRNA调控网络控制几个众所周知的T细胞急性淋巴细胞白血病肿瘤抑制基因，包括PHF6，是非常重要的。鉴于PHF6病变的高频率
In this context, our previous description of a cooperative microRNA regulatory network controlling several well-known T-cell acute lymphobla …
Structural and functional insights into the human Borjeson-Forssman-Lehmann syndrome-associated protein PHF6.
人类Borjeson-Forssman-Lehmann综合征相关蛋白PHF 6的结构和功能见解。 The Journal of Biological Chemistry生物学TOPEI检索SCI升级版 生物学2区SCI基础版 生物2区IF 4.8
Liu Z, Li F, Ruan K, Zhang J, Mei Y, Wu J, Shi Y. Liu Z, et al. J Biol Chem. 2014 Apr 4;289(14):10069-83. doi: 10.1074/jbc.M113.535351. Epub 2014 Feb 19. J Biol Chem. 2014. PMID: 24554700 Free PMC article.
PHF6-ePHD2 appears to fold as a novel integrated structural module. Structural analysis of PHF6-ePHD2 reveals pathological implication of PHF6 gene mutations in Borjeson-Forssman-Lehmann syndrome, T-cell acute lymphoblastic leukemia, and acute myeloid leukemi …
PHF 6-ePHD 2似乎作为一种新的整合结构模块折叠。PHF 6-ePHD 2的结构分析揭示了PHF 6基因突变在Borjeson-Forssman-Lehmann综合征、T细胞急性淋巴细胞白血病和急性髓性白血病中的病理意义。
PHF6-ePHD2 appears to fold as a novel integrated structural module. Structural analysis of PHF6-ePHD2 reveals pathological imp …
Transcriptional expressions of hsa-mir-183 predicted target genes as independent indicators for prognosis in bladder urothelial carcinoma.
hsa-mir-183转录表达预测靶基因作为膀胱尿路上皮癌预后的独立指标。 Aging-usSCI升级版 医学3区SCI基础版 医学2区IF 5.2
Li M, Xu DM, Lin SB, Yang ZL, Xu TY, Yang JH, Lin ZX, Huang ZK, Yin J. Li M, et al. Aging (Albany NY). 2022 May 3;14(9):3782-3800. doi: 10.18632/aging.204040. Epub 2022 May 3. Aging (Albany NY). 2022. PMID: 35503998 Free PMC article.
METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Metascape, Kaplan-Meier plotter, Human Protein Atlas, TIMER2.0, cBioPortal and Genomics of Drug Sensitivity in Cancer databases. RESULTS: …
方法：为了解决这个问题，我们的研究通过UALCAN，Metascape，Kaplan-Meier RT-PCR，Human Protein Atlas，TIMER2.0，cBioPortal和Genomics of Drug Sensitivity in Cancer数据库探索了hsa-mir-183预测靶基因在BLCA预后中的作用。结果：.
METHODS: To address this issue, our study explored the roles of hsa-mir-183 predicted target genes in the prognosis of BLCA via UALCAN, Meta …
PHF6 regulates phenotypic plasticity through chromatin organization within lineage-specific genes.
PHF 6通过谱系特异性基因内的染色质组织来调节表型可塑性。 Genes & Development生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 10.5
Soto-Feliciano YM, Bartlebaugh JME, Liu Y, Sánchez-Rivera FJ, Bhutkar A, Weintraub AS, Buenrostro JD, Cheng CS, Regev A, Jacks TE, Young RA, Hemann MT. Soto-Feliciano YM, et al. Genes Dev. 2017 May 15;31(10):973-989. doi: 10.1101/gad.295857.117. Epub 2017 Jun 12. Genes Dev. 2017. PMID: 28607179 Free PMC article.
Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromatin accessibility to lineage-specific transcription factors. We show that loss of Phf6 in B-cell leukemia results in systematic change …
在这里，我们描述了植物同源结构域指蛋白6（PHF6）在白血病中的功能，并定义其在调节染色质对谱系特异性转录因子的可及性中的作用。我们表明，在B细胞白血病中Phf6的损失导致系统性变化。
Here, we describe the function of the plant homeodomain finger protein 6 (PHF6) in leukemia and define its role in regulating chromat …
Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation.
Notoprotein R1通过PHF 6蛋白诱导DNA损伤抑制宫颈癌细胞增殖 Molecular Medicine ReportsSCI升级版 医学3区SCI基础版 医学4区IF 3.4
Cai T, Wu W, Guo L, Xia Y, Jiang X, Zhang L, Peng F, Ming P. Cai T, et al. Mol Med Rep. 2021 Apr;23(4):242. doi: 10.3892/mmr.2021.11881. Epub 2021 Feb 4. Mol Med Rep. 2021. PMID: 33537816 Free PMC article.
Notoginsenoside R1 (NGR1), a monomer of Traditional Chinese medicine, is from the Panax notoginsenoside complex, and has been reported to inhibit the proliferation of various types of cancer. However the mechanism underlying NGR1-mediated inhibition of cervical carcinoma c …
三七皂苷R1（NGR1）是中药三七皂苷复合物中的一种单体化合物，具有抑制多种肿瘤细胞增殖的作用。但NGR1介导的宫颈癌抑制机制尚不清楚。
Notoginsenoside R1 (NGR1), a monomer of Traditional Chinese medicine, is from the Panax notoginsenoside complex, and has been reported to in …
PHF6 and DNMT3A mutations are enriched in distinct subgroups of mixed phenotype acute leukemia with T-lineage differentiation.
PHF 6和DNMT 3A突变在具有T系分化的混合表型急性白血病的不同亚组中富集。 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.6
Xiao W, Bharadwaj M, Levine M, Farnhoud N, Pastore F, Getta BM, Hultquist A, Famulare C, Medina JS, Patel MA, Gao Q, Lewis N, Pichardo J, Baik J, Shaffer B, Giralt S, Rampal R, Devlin S, Cimera R, Zhang Y, E Arcila M, Papaemmanuil E, Levine RL, Roshal M. Xiao W, et al. Blood Adv. 2018 Dec 11;2(23):3526-3539. doi: 10.1182/bloodadvances.2018023531. Blood Adv. 2018. PMID: 30530780 Free PMC article.
These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked predilection for T-lineage differentiation (5/6 PHF6 mutated, 6/6 DNMT3A mutated). ...Sequencing studies on flow-cytometry-sorted popula …
这些突变相互排斥，BCR-ABL 1/MLL易位。PHF 6和DNMT 3A突变的MPAL显示出对T系分化的显著偏好（5/6个PHF 6突变，6/6个DNMT 3A突变）。...流式细胞术分选的群体基因的测序研究
These mutations are mutually exclusive of each other and BCR-ABL1/MLL translocations. PHF6- and DNMT3A-mutated MPAL showed marked pre …
Detection of an activated JAK3 variant and a Xq26.3 microdeletion causing loss of PHF6 and miR-424 expression in myelodysplastic syndromes by combined targeted next generation sequencing and SNP array analysis.
通过联合靶向下一代测序和SNP阵列分析检测骨髓增生异常综合征中导致PHF 6和miR-424表达丧失的激活JAK 3变体和Xq26.3微缺失 Pathology Research And PracticeSCI升级版 医学4区SCI基础版 医学4区IF 2.8
Kunze K, Gamerdinger U, Leßig-Owlanj J, Sorokina M, Brobeil A, Tur MK, Blau W, Burchardt A, Käbisch A, Schliesser G, Kiehl M, Rosenwald A, Rummel M, Grimminger F, Hain T, Chakraborty T, Bräuninger A, Gattenlöhner S. Kunze K, et al. Pathol Res Pract. 2014 Jun;210(6):369-76. doi: 10.1016/j.prp.2014.02.006. Epub 2014 Feb 23. Pathol Res Pract. 2014. PMID: 24674452
Therefore and in order to cover the entire bone marrow microenvironment involved in the pathogenesis of MDS, SNP array analysis and targeted next generation sequencing (tNGS) for the mostly therapy relevant 46 onco- and tumor-suppressor genes were performed on bone marrow …
因此，为了覆盖MDS发病机制中涉及的整个骨髓微环境，对骨髓中与治疗相关的46个肿瘤和肿瘤抑制基因进行了SNP阵列分析和靶向下一代测序（tNGS）。
Therefore and in order to cover the entire bone marrow microenvironment involved in the pathogenesis of MDS, SNP array analysis and targeted …
Somatic Mutational Profile of High-Grade Serous Ovarian Carcinoma and Triple-Negative Breast Carcinoma in Young and Elderly Patients: Similarities and Divergences.
年轻和老年患者中高级别浆液性卵巢癌和三阴性乳腺癌的体细胞突变谱：相似性和差异性。 CellsSCI升级版 生物学2区SCI基础版 生物2区IF 6.0
Serio PAMP, de Lima Pereira GF, Katayama MLH, Roela RA, Maistro S, Folgueira MAAK. Serio PAMP, et al. Cells. 2021 Dec 20;10(12):3586. doi: 10.3390/cells10123586. Cells. 2021. PMID: 34944094 Free PMC article.
BACKGROUND: Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that share similarities; however, different ages of onset may reflect distinct tumor behaviors. ...METHODS: Open access mutational data ( …
背景技术背景：三阴性乳腺癌（TNBC）和高级别浆液性卵巢癌（HGSOC）是具有相似性的侵袭性恶性肿瘤;然而，不同的发病年龄可能反映不同的肿瘤行为。...方法：开放获取突变数据（…
BACKGROUND: Triple-negative breast cancer (TNBC) and High-Grade Serous Ovarian Cancer (HGSOC) are aggressive malignancies that …
PHF6 mutations in T-cell acute lymphoblastic leukemia.
T细胞急性淋巴细胞白血病中的PHF 6突变 Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 30.8
Van Vlierberghe P, Palomero T, Khiabanian H, Van der Meulen J, Castillo M, Van Roy N, De Moerloose B, Philippé J, González-García S, Toribio ML, Taghon T, Zuurbier L, Cauwelier B, Harrison CJ, Schwab C, Pisecker M, Strehl S, Langerak AW, Gecz J, Sonneveld E, Pieters R, Paietta E, Rowe JM, Wiernik PH, Benoit Y, Soulier J, Poppe B, Yao X, Cordon-Cardo C, Meijerink J, Rabadan R, Speleman F, Ferrando A. Van Vlierberghe P, et al. Nat Genet. 2010 Apr;42(4):338-42. doi: 10.1038/ng.542. Epub 2010 Mar 14. Nat Genet. 2010. PMID: 20228800 Free PMC article.
Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. ...Overall, these results identify PHF6 as a new X-linked tumor suppressor in T-ALL and point to a strong genetic interaction between PHF6 l …
X染色体上的肿瘤抑制基因可能会使特定类型癌症的性别分布发生倾斜。...总的来说，这些结果将PHF 6确定为T-ALL中的一种新的X连锁肿瘤抑制因子，并指出PHF 6与T-ALL之间存在强烈的遗传相互作用。
Tumor suppressor genes on the X chromosome may skew the gender distribution of specific types of cancer. ...Overall, these res …
Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway.
Circ_0039569通过靶向miR-1271- 5 p/PHF 6通路促进子宫内膜癌的紫杉醇耐药。 Anti-cancer DrugsSCI升级版 医学4区SCI基础版 医学4区IF 2.3
Li J, Zhang Z, Hu Y, Wei Q, Shao X. Li J, et al. Anticancer Drugs. 2022 Oct 1;33(9):883-892. doi: 10.1097/CAD.0000000000001377. Epub 2022 Sep 14. Anticancer Drugs. 2022. PMID: 36136988
However, whether circ_0039569 mediates the chemoresistance of endometrial cancer (EC) remains unclear. Quantitative real-time PCR was performed to analyze circ_0039569, microRNA (miR)-1271-5p and PHD finger protein 6 (PHF6) expression. ...Also, interference of circ_ …
然而，circ_0039569是否介导子宫内膜癌（EC）的化疗耐药性仍不清楚。进行定量实时PCR以分析circ_0039569、微小RNA（miR）-1271-5p和PHD指蛋白6（PHF 6）表达。...此外，还讨论了电路的干扰问题。
However, whether circ_0039569 mediates the chemoresistance of endometrial cancer (EC) remains unclear. Quantitative real-time PCR was …
Clinical and molecular predictors of long-term response in HER2 positive metastatic breast cancer patients.
HER2阳性转移性乳腺癌患者长期缓解的临床和分子预测因子 Cancer Biology & TherapySCI升级版 医学4区SCI基础版 医学3区IF 3.6
Omarini C, Bettelli S, Caprera C, Manfredini S, Caggia F, Guaitoli G, Moscetti L, Toss A, Cortesi L, Kaleci S, Maiorana A, Cascinu S, Conte PF, Piacentini F. Omarini C, et al. Cancer Biol Ther. 2018;19(10):879-886. doi: 10.1080/15384047.2018.1480287. Epub 2018 Aug 1. Cancer Biol Ther. 2018. PMID: 30067438 Free PMC article.
BACKGROUND: HER2+ metastatic breast cancer (MBC) is a poor prognosis disease, unusually curable. To date, no predictive factors have been clearly correlated with long-term response to anti-HER2 agents. ...Further clinical implications are warranted. ABBREVIATIONS: BC: brea …
背景：HER 2+转移性乳腺癌（MBC）是一种预后不良的疾病，通常可治愈。迄今为止，没有预测因素与抗HER 2药物的长期应答明确相关。...进一步的临床意义是必要的。缩写：BC：brea.
BACKGROUND: HER2+ metastatic breast cancer (MBC) is a poor prognosis disease, unusually curable. To date, no predictive factors have …
PHF6 mutations in adult acute myeloid leukemia.
成人急性髓系白血病中的PHF6突变 Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 11.4
Van Vlierberghe P, Patel J, Abdel-Wahab O, Lobry C, Hedvat CV, Balbin M, Nicolas C, Payer AR, Fernandez HF, Tallman MS, Paietta E, Melnick A, Vandenberghe P, Speleman F, Aifantis I, Cools J, Levine R, Ferrando A. Van Vlierberghe P, et al. Leukemia. 2011 Jan;25(1):130-4. doi: 10.1038/leu.2010.247. Epub 2010 Oct 29. Leukemia. 2011. PMID: 21030981 Free PMC article.
As in the case of T-ALL, where PHF6 alterations are found almost exclusively in males, mutations in PHF6 were seven times more prevalent in males than in females with AML. Overall, these results identify PHF6 as a tumor suppressor gene mutated in AML a …
在T-ALL的情况下，PHF 6的改变几乎只在男性中发现，PHF 6的突变在男性中的发生率是AML女性的7倍。总的来说，这些结果确定PHF 6作为一个肿瘤抑制基因突变的AML和白血病。
As in the case of T-ALL, where PHF6 alterations are found almost exclusively in males, mutations in PHF6 were seven times more …
PHF6 loss reduces leukemia stem cell activity in an acute myeloid leukemia mouse model.
PHF6缺失降低急性髓性白血病小鼠模型中白血病干细胞活性 Cancer Cell InternationalSCI升级版 医学2区SCI基础版 医学2区IF 5.8
Yuan S, Gao M, Wang Y, Lan Y, Li M, Du Y, Li Y, Ju W, Huang Y, Yuan K, Zeng L. Yuan S, et al. Cancer Cell Int. 2024 Feb 9;24(1):66. doi: 10.1186/s12935-024-03265-w. Cancer Cell Int. 2024. PMID: 38336746 Free PMC article.
In our study, we knocked out the Phf6 gene at different disease stages in the AML mice model. Moreover, we knocked down PHF6 by shRNA in two AML cell lines and examined the cell growth, apoptosis, and cell cycle. ...The expressions of genes related to cell different …
在我们的研究中，我们在AML小鼠模型的不同疾病阶段敲除了Phf 6基因。此外，我们敲低PHF 6在两个AML细胞系，并检查细胞生长，凋亡和细胞周期。...与细胞差异相关的基因表达。
In our study, we knocked out the Phf6 gene at different disease stages in the AML mice model. Moreover, we knocked down PHF6 b …
Clinicopathological Characteristics and Mutational Profiling of Adult T-Cell Lymphoblastic Lymphoma in a Chinese Population.
中国成人T细胞淋巴母细胞性淋巴瘤的临床病理特征和突变谱 Cancer Management And ResearchSCI升级版 医学4区SCI基础版 医学3区IF 3.3
Chen F, Pang D, Guo H, Jiang X, Liu S, Huang L, Wei X, Liang Z, Wang X, Li W. Chen F, et al. Cancer Manag Res. 2020 Apr 30;12:3003-3012. doi: 10.2147/CMAR.S242903. eCollection 2020. Cancer Manag Res. 2020. PMID: 32431543 Free PMC article.
Chidamide maintenance was used in five patients exhibiting unfavorable genetic alterations, with no evidence of relapse. Next-generation sequencing of pretreatment tumor tissue was undertaken for 15 patients. NOTCH1 mutations were the most frequent genetic alterations, fol …
西达胺维持治疗用于5例表现出不利遗传改变的患者，无复发证据。对15名患者进行了治疗前肿瘤组织的下一代测序。NOTCH 1突变是最常见的遗传改变，其次是突变。
Chidamide maintenance was used in five patients exhibiting unfavorable genetic alterations, with no evidence of relapse. Next-generation seq …
Clinical and biological features of PTPN2-deleted adult and pediatric T-cell acute lymphoblastic leukemia.
PTPN2缺失的成人和儿童T细胞急性淋巴细胞白血病的临床和生物学特征 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.6
Alcantara M, Simonin M, Lhermitte L, Touzart A, Dourthe ME, Latiri M, Grardel N, Cayuela JM, Chalandon Y, Graux C, Dombret H, Ifrah N, Petit A, Macintyre E, Baruchel A, Boissel N, Asnafi V. Alcantara M, et al. Blood Adv. 2019 Jul 9;3(13):1981-1988. doi: 10.1182/bloodadvances.2018028993. Blood Adv. 2019. PMID: 31270080 Free PMC article.
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphoblastic leukemia (T-ALL). ...Analysis of the mutational genotype of adult T-ALL revealed a positive correlation between PTPN2 deletions and ga …
蛋白酪氨酸磷酸酶非受体2型（PTPN 2）是一种磷酸酶，已知是T细胞急性淋巴细胞白血病（T-ALL）的肿瘤抑制基因。...成人T-ALL的突变基因型分析显示PTPN 2缺失与遗传易感性呈正相关。
Protein tyrosine phosphatase nonreceptor type 2 (PTPN2) is a phosphatase known to be a tumor suppressor gene in T-cell acute lymphobl …
Proteomic Comparison of Malignant Human Germ Cell Tumor Cell Lines.
恶性生殖细胞肿瘤细胞系的蛋白质组学比较。 Disease MarkersSCI基础版 医学3区
Bremmer F, Bohnenberger H, Küffer S, Oellerich T, Serve H, Urlaub H, Strauss A, Maatoug Y, Behnes CL, Oing C, Radzun HJ, Ströbel P, Balabanov S, Honecker F. Bremmer F, et al. Dis Markers. 2019 Sep 3;2019:8298524. doi: 10.1155/2019/8298524. eCollection 2019. Dis Markers. 2019. PMID: 31565104 Free PMC article.
We were able to identify 4856 proteins and quantify the expression of 3936. 347 were significantly differentially expressed between the two cell lines. For further validation, CD81, CBX-3, PHF6, and ENSA were analyzed by western blot analysis. The results confirmed the MS …
我们能够识别4856种蛋白质并定量3936种蛋白质的表达。347在两种细胞系之间显著差异表达。为了进一步验证，通过蛋白质印迹分析来分析⑶ 81、CBX-3、PHF 6和ENSA。结果显示，MS…
We were able to identify 4856 proteins and quantify the expression of 3936. 347 were significantly differentially expressed between the two …
Coffin-Siris syndrome and related disorders involving components of the BAF (mSWI/SNF) complex: historical review and recent advances using next generation sequencing.
Coffin-Siris综合征和涉及BAF（mSWI/SNF）复合物组分的相关疾病：历史回顾和使用下一代测序的最新进展 American Journal of Medical Genetics Part C-seminars in Medical GeneticsSCI升级版 医学3区SCI基础版 医学2区IF 3.1
American Journal of Medical Genetics Part C-seminars in Medical GeneticsSCI升级版医学3区SCI基础版医学2区IF 3.1
Kosho T, Miyake N, Carey JC. Kosho T, et al. Am J Med Genet C Semin Med Genet. 2014 Sep;166C(3):241-51. doi: 10.1002/ajmg.c.31415. Epub 2014 Aug 28. Am J Med Genet C Semin Med Genet. 2014. PMID: 25169878 Review.
In 2012, 42 years after the first description of CSS in 1970, five causative genes (SMARCB1, SMARCE1, SMARCA4, ARID1A, ARID1B), all encoding components of the BAF complex, were identified as being responsible for CSS through whole exome sequencing and pathway-based genetic screen …
2012年，在1970年首次描述CSS的42年后，通过全外显子组测序和基于通路的遗传筛选，确定了五个致病基因（SMARCB 1，SMARCE 1，SMARCA 4，ARID 1A，ARID 1B），所有BAF复合物的编码组分，负责CSS。
In 2012, 42 years after the first description of CSS in 1970, five causative genes (SMARCB1, SMARCE1, SMARCA4, ARID1A, ARID1B), all encoding …
Integrated genomic sequencing in myeloid blast crisis chronic myeloid leukemia (MBC-CML), identified potentially important findings in the context of leukemogenesis model.
整合基因组测序在髓系原始细胞危象慢性粒细胞白血病（MBC-CML），确定了潜在的重要发现，在白血病模型的背景下。 Scientific ReportsSCI升级版 综合性期刊2区SCI基础版 综合性期刊3区IF 4.6
Kazemi-Sefat GE, Keramatipour M, Vaezi M, Razavi SM, Kavousi K, Talebi A, Rostami S, Yaghmaie M, Chahardouli B, Talebi S, Mousavizadeh K. Kazemi-Sefat GE, et al. Sci Rep. 2022 Jul 27;12(1):12816. doi: 10.1038/s41598-022-17232-w. Sci Rep. 2022. PMID: 35896598 Free PMC article.
An in-house filtering pipeline was applied to assess important variants in cancer-related genes. Standard variant interpretation guidelines were used for the interpretation of potentially important findings (PIFs) and potentially actionable findings (PAFs). Single nucleoti …
应用内部过滤管道来评估癌症相关基因中的重要变体。使用标准变量解释指南解释潜在重要发现（PIF）和潜在可行发现（PAF）。单核苷酸
An in-house filtering pipeline was applied to assess important variants in cancer-related genes. Standard variant interpretation guid …
Complex karyotype in de novo acute myeloid leukemia: typical and atypical subtypes differ molecularly and clinically.
初发急性髓细胞白血病的复杂核型：典型和非典型亚型在分子和临床上的不同。 Leukemia医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 11.4
Mrózek K, Eisfeld AK, Kohlschmidt J, Carroll AJ, Walker CJ, Nicolet D, Blachly JS, Bill M, Papaioannou D, Wang ES, Uy GL, Kolitz JE, Powell BL, Blum W, Stone RM, Byrd JC, Bloomfield CD. Mrózek K, et al. Leukemia. 2019 Jul;33(7):1620-1634. doi: 10.1038/s41375-019-0390-3. Epub 2019 Feb 8. Leukemia. 2019. PMID: 30737482 Free PMC article.
Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated genes in 160 clinically well-characterized patients. ...Patients with atypical CK-AML differed from those with typical CK-AML: they carried TP5 …
由于CK-AML的分子特征尚未得到很好的表征，我们研究了160例临床特征良好的患者中81个白血病/癌症相关基因的突变状态。...非典型CK-AML患者与典型CK-AML患者不同：他们携带TP 5，...
Since molecular features of CK-AML are not well characterized, we investigated mutational status of 81 leukemia/cancer-associated gen …
3' UTR shortening represses tumor-suppressor genes in trans by disrupting ceRNA crosstalk.
3' UTR缩短通过破坏ceRNA串扰来反式抑制肿瘤抑制基因。 Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 30.8
Park HJ, Ji P, Kim S, Xia Z, Rodriguez B, Li L, Su J, Chen K, Masamha CP, Baillat D, Fontes-Garfias CR, Shyu AB, Neilson JR, Wagner EJ, Li W. Park HJ, et al. Nat Genet. 2018 Jun;50(6):783-789. doi: 10.1038/s41588-018-0118-8. Epub 2018 May 21. Nat Genet. 2018. PMID: 29785014 Free PMC article.
MAT3UTR predicts many trans-targets of 3' UTR shortening, including PTEN, a crucial tumor-suppressor gene (3) involved in ceRNA crosstalk (4) with nine 3'UTR-shortening genes, including EPS15 and NFIA. Knockdown of NUDT21, a master 3' UTR-shortening regulator (2) , repress …
MAT 3UTR预测了许多3' UTR缩短的反式靶点，包括PTEN，一种参与ceRNA与9个3' UTR缩短基因（包括EPS15和NFIA）串扰的关键肿瘤抑制基因（3）。NUDT 21的敲除，一个主要的3'UTR缩短调节器（2），抑制...
MAT3UTR predicts many trans-targets of 3' UTR shortening, including PTEN, a crucial tumor-suppressor gene (3) involved in ceRNA cross …
A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL).
急性T淋巴细胞白血病（T-ALL）中microRNA-肿瘤抑制基因协同网络 Nature Genetics生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 30.8
Mavrakis KJ, Van Der Meulen J, Wolfe AL, Liu X, Mets E, Taghon T, Khan AA, Setty M, Rondou P, Vandenberghe P, Delabesse E, Benoit Y, Socci NB, Leslie CS, Van Vlierberghe P, Speleman F, Wendel HG. Mavrakis KJ, et al. Nat Genet. 2011 Jun 5;43(7):673-8. doi: 10.1038/ng.858. Nat Genet. 2011. PMID: 21642990 Free PMC article.
Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7. Thus, a comprehensive and unbiased analysis of miRNA action …
此外，这些miRNA对T-ALL发病机制中涉及的肿瘤抑制基因产生重叠和协同作用，包括IKAROS（也称为IKZF 1），PTEN，BIM，PHF 6，NF 1和FBXW 7。因此，对miRNA作用的全面和无偏见的分析…
Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, …
CRLF2 overexpression defines an immature-like subgroup which is rescued through restoration of the PRC2 function in T-cell precursor acute lymphoblastic leukemia.
CRLF 2过表达定义了一个不成熟样亚群，通过恢复T细胞前体急性淋巴细胞白血病中的PRC 2功能来挽救。 Genes Chromosomes & CancerSCI升级版 医学2区SCI基础版 医学3区IF 3.7
Maciel ALT, Wolch K, Emerenciano M, Mansur MB. Maciel ALT, et al. Genes Chromosomes Cancer. 2022 Jul;61(7):437-442. doi: 10.1002/gcc.23036. Epub 2022 Mar 16. Genes Chromosomes Cancer. 2022. PMID: 35253299
In the present study, we aimed to unravel the genomic profile underlying CRLF2 overexpression (CRLF2-high) by analyzing RNA-seq, WES, and SNP-array data from 264 T-ALL patients and five cell lines deposited on the TARGET initiative, Cancer Cell Line Encyclopedia and Gene E …
在本研究中，我们的目的是通过分析来自264名T-ALL患者和5个细胞系的RNA-seq，WES和SNP阵列数据来揭示CRLF 2过表达（CRLF 2-high）的基因组谱，这些细胞系存放在TARGET计划，癌细胞系百科全书和基因工程中。
In the present study, we aimed to unravel the genomic profile underlying CRLF2 overexpression (CRLF2-high) by analyzing RNA-seq, WES, and SN …
Genomic and clinical characterization of B/T mixed phenotype acute leukemia reveals recurrent features and T-ALL like mutations.
B/T混合表型急性白血病的基因组和临床特征揭示了复发特征和T-ALL样突变 American Journal of Hematology医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 12.8
Mi X, Griffin G, Lee W, Patel S, Ohgami R, Ok CY, Wang S, Geyer JT, Xiao W, Roshal M, Garcia JS, Silverman LB, Sallan SE, Aster JC, Harris MH, Weinberg OK. Mi X, et al. Am J Hematol. 2018 Nov;93(11):1358-1367. doi: 10.1002/ajh.25256. Epub 2018 Sep 26. Am J Hematol. 2018. PMID: 30117174 Free PMC article.
While the tumors have diverse cytogenetic and genomic perturbations, recurrent acquired aberrations include mutations in the putative transcriptional regulator PHF6 and the JAK-STAT and Ras signaling pathways. Alterations were also identified in genes encoding hematopoieti …
虽然肿瘤具有不同的细胞遗传学和基因组扰动，复发性获得性畸变包括假定的转录调节因子PHF 6和JAK-STAT和Ras信号通路中的突变。在编码造血干细胞的基因中也发现了改变。
While the tumors have diverse cytogenetic and genomic perturbations, recurrent acquired aberrations include mutations in the putative transc …
Modeling Global Genomic Instability in Chronic Myeloid Leukemia (CML) Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs).
使用患者衍生的诱导多能干细胞（iPSC）建模慢性髓性白血病（CML）的全球基因组不稳定性。 Cancers中科院预警 引用操纵SCI升级版 医学2区SCI基础版 医学2区IF 5.2
Telliam G, Desterke C, Imeri J, M'kacher R, Oudrhiri N, Balducci E, Fontaine-Arnoux M, Acloque H, Bennaceur-Griscelli A, Turhan AG. Telliam G, et al. Cancers (Basel). 2023 May 3;15(9):2594. doi: 10.3390/cancers15092594. Cancers (Basel). 2023. PMID: 37174060 Free PMC article.
CGH array performed for both conditions in two different time points reveals several cancer genes in the ENU-treated condition, some known to be altered in leukemia (BLM, IKZF1, NCOA2, ALK, EP300, ERG, MKL1, PHF6 and TET1). ...
在两个不同时间点对两种条件进行的CGH阵列揭示了ENU处理条件下的几种癌症基因，其中一些已知在白血病中发生改变（BLM、IKZF 1、NCOA 2、ALK、EP 300、ERG、MKL 1、PHF 6和TET 1）。...
CGH array performed for both conditions in two different time points reveals several cancer genes in the ENU-treated condition, some …
Genomic characterization of pediatric T-cell acute lymphoblastic leukemia reveals novel recurrent driver mutations.
儿童T细胞急性淋巴细胞白血病的基因组特征揭示了新的复发性驱动突变 Oncotarget
Spinella JF, Cassart P, Richer C, Saillour V, Ouimet M, Langlois S, St-Onge P, Sontag T, Healy J, Minden MD, Sinnett D. Spinella JF, et al. Oncotarget. 2016 Oct 4;7(40):65485-65503. doi: 10.18632/oncotarget.11796. Oncotarget. 2016. PMID: 27602765 Free PMC article.
Using an integrative approach combining genomic and transcriptomic data, we molecularly characterized 30 pediatric T-ALLs and identified common recurrent T-ALL targets such as FBXW7, JAK1, JAK3, PHF6, KDM6A and NOTCH1 as well as novel candidate T-ALL driver mutations inclu …
使用结合基因组和转录组学数据的综合方法，我们对30种儿科T-ALL进行了分子特征分析，并确定了常见的复发性T-ALL靶点，如FBXW 7、JAK 1、JAK 3、PHF 6、KDM 6A和NOTCH 1，以及新的候选T-ALL驱动突变，包括T-ALL基因突变。
Using an integrative approach combining genomic and transcriptomic data, we molecularly characterized 30 pediatric T-ALLs and identified com …
Plexiform Neurofibroma With Activating KRAS Mutation and Segmental Presentation Involving the Unilateral Eyelid.
累及单侧眼睑的KRAS激活突变和节段性表现的丛状神经纤维瘤。 Ophthalmic Plastic And Reconstructive SurgerySCI升级版 医学4区SCI基础版 医学4区IF 2.0
Ophthalmic Plastic And Reconstructive Surgery SCI升级版医学4区SCI基础版医学4区IF 2.0
Stallworth JY, Smith LD, Vagefi MR, Pekmezci M. Stallworth JY, et al. Ophthalmic Plast Reconstr Surg. 2022 Jul-Aug 01;38(4):e104-e106. doi: 10.1097/IOP.0000000000002147. Epub 2022 Mar 21. Ophthalmic Plast Reconstr Surg. 2022. PMID: 35797671
While suggestive of segmental neurofibromatosis, genetic analysis revealed activating KRAS mutation and inactivating mutation in PHF6 with no evidence of NF1 mutation in germline or tumor tissue. Neither KRAS nor PHF6 have been previously reported in associat …
While suggestive of segmental neurofibromatosis, genetic analysis revealed activating KRAS mutation and inactivating mutation in PHF6 …
Monitoring of clonal evolution of acute myeloid leukemia identifies the leukemia subtype, clinical outcome and potential new drug targets for post-remission strategies or relapse.
监测急性髓性白血病的克隆演变可确定白血病亚型、临床结局和缓解后策略或复发的潜在新药靶点。 Haematologica医学TOPSCI升级版 医学1区SCI基础版 医学1区IF 10.1
Onecha E, Rapado I, Luz Morales M, Carreño-Tarragona G, Martinez-Sanchez P, Gutierrez X, Sáchez Pina JM, Linares M, Gallardo M, Martinez-López J, Ayala R. Onecha E, et al. Haematologica. 2021 Sep 1;106(9):2325-2333. doi: 10.3324/haematol.2020.254623. Haematologica. 2021. PMID: 32732356 Free PMC article.
The most frequently affected pathways in patients with primary refractoriness were signaling, transcription and tumor suppression, whereas methylation and splicing pathways were mainly implicated in relapsed patients. ...Specifically, 100% of variants in EZH2, RUNX1, VHL, …
The most frequently affected pathways in patients with primary refractoriness were signaling, transcription and tumor suppression, wh …
Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia.
儿科前体B细胞急性淋巴细胞白血病驱动基因突变及其临床影响的概况 Blood Advances医学TOPSCI升级版 医学1区SCI基础版 医学2区IF 7.6
Ueno H, Yoshida K, Shiozawa Y, Nannya Y, Iijima-Yamashita Y, Kiyokawa N, Shiraishi Y, Chiba K, Tanaka H, Isobe T, Seki M, Kimura S, Makishima H, Nakagawa MM, Kakiuchi N, Kataoka K, Yoshizato T, Nishijima D, Deguchi T, Ohki K, Sato A, Takahashi H, Hashii Y, Tokimasa S, Hara J, Kosaka Y, Kato K, Inukai T, Takita J, Imamura T, Miyano S, Manabe A, Horibe K, Ogawa S, Sanada M. Ueno H, et al. Blood Adv. 2020 Oct 27;4(20):5165-5173. doi: 10.1182/bloodadvances.2019001307. Blood Adv. 2020. PMID: 33095873 Free PMC article.
In addition, positive correlations were also newly reported between TCF3-PBX1 ALL with PHF6 mutations. In multivariate Cox proportional hazards regression models for overall survival, TP53 mutation/deletion, hypodiploid, and MEF2D fusions were selected in both cohorts. ... …
此外，TCF 3-PBX 1 ALL与PHF 6突变之间也有新的正相关报道。在总生存期的多变量考克斯比例风险回归模型中，在两个队列中选择TP 53突变/缺失、亚二倍体和MEF 2D融合。...…
In addition, positive correlations were also newly reported between TCF3-PBX1 ALL with PHF6 mutations. In multivariate Cox proportion …
A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.
基因组规模的体内功能丧失筛选鉴定Phf6为白血病细胞生长的谱系特异性调节剂。 Genes & Development生物学TOPSCI升级版 生物学1区SCI基础版 生物1区IF 10.5
Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT. Meacham CE, et al. Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114. Genes Dev. 2015. PMID: 25737277 Free PMC article.
These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in human myeloid and T-cell malignancies, we found that Phf6 suppression in B-cell malignancies impairs tumor progression. Thus, …
其中包括编码锌指蛋白Phf6的基因。虽然在人类骨髓和T细胞恶性肿瘤中经常观察到PHF6的失活突变，但我们发现，在B细胞恶性肿瘤中抑制PHF6会损害肿瘤进展。因此，
These included the gene encoding the zinc finger protein Phf6. While inactivating mutations in PHF6 are commonly observed in h …
High accuracy mutation detection in leukemia on a selected panel of cancer genes.
白血病中一组选定癌症基因的高准确度突变检测。 Plos OneSCI升级版 综合性期刊3区SCI基础版 综合性期刊3区IF 3.7
Kalender Atak Z, De Keersmaecker K, Gianfelici V, Geerdens E, Vandepoel R, Pauwels D, Porcu M, Lahortiga I, Brys V, Dirks WG, Quentmeier H, Cloos J, Cuppens H, Uyttebroeck A, Vandenberghe P, Cools J, Aerts S. Kalender Atak Z, et al. PLoS One. 2012;7(6):e38463. doi: 10.1371/journal.pone.0038463. Epub 2012 Jun 4. PLoS One. 2012. PMID: 22675565 Free PMC article.
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming available for many cancer types. Increasing access to sequencing technology, including bench-top sequencers, provide the opportunity to …
随着全基因组和全外显子组测序的出现，许多癌症类型的复发突变癌症基因的高质量目录变得可用。越来越多的测序技术，包括台式测序仪，提供了机会...
With the advent of whole-genome and whole-exome sequencing, high-quality catalogs of recurrently mutated cancer genes are becoming av …
Genetic mutational analysis of pediatric acute lymphoblastic leukemia from a single center in China using exon sequencing.
应用外显子测序分析中国单中心儿童急性淋巴细胞白血病的基因突变 Bmc Cancer医学TOPSCI升级版 医学2区SCI基础版 医学3区IF 3.8
Zhang H, Wang H, Qian X, Gao S, Xia J, Liu J, Cheng Y, Man J, Zhai X. Zhang H, et al. BMC Cancer. 2020 Mar 12;20(1):211. doi: 10.1186/s12885-020-6709-7. BMC Cancer. 2020. PMID: 32164600 Free PMC article.
METHODS: Using next-generation sequencing (NGS) in matched germline and tumor samples from 140 pediatric Chinese patients with ALL, we landscaped the gene mutations and estimated the mutation frequencies in this disease. ...While the most frequently mutated genes were KRAS …
方法：我们使用下一代测序技术（NGS）对140例ALL患儿的生殖细胞和肿瘤样本进行了基因突变检测，并估计了该疾病的突变频率。...虽然最常见的突变基因是KRAS...
METHODS: Using next-generation sequencing (NGS) in matched germline and tumor samples from 140 pediatric Chinese patients with ALL, w …
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes.
1,000个儿科癌症基因组中表观遗传调节因子的体细胞突变景观。 Nature Communications综合性期刊TOPSCI升级版 综合性期刊1区SCI基础版 综合性期刊1区IF 16.6
Huether R, Dong L, Chen X, Wu G, Parker M, Wei L, Ma J, Edmonson MN, Hedlund EK, Rusch MC, Shurtleff SA, Mulder HL, Boggs K, Vadordaria B, Cheng J, Yergeau D, Song G, Becksfort J, Lemmon G, Weber C, Cai Z, Dang J, Walsh M, Gedman AL, Faber Z, Easton J, Gruber T, Kriwacki RW, Partridge JF, Ding L, Wilson RK, Mardis ER, Mullighan CG, Gilbertson RJ, Baker SJ, Zambetti G, Ellison DW, Zhang J, Downing JR. Huether R, et al. Nat Commun. 2014 Apr 8;5:3630. doi: 10.1038/ncomms4630. Nat Commun. 2014. PMID: 24710217 Free PMC article.
The most frequently mutated genes are H3F3A, PHF6, ATRX, KDM6A, SMARCA4, ASXL2, CREBBP, EZH2, MLL2, USP7, ASXL1, NSD2, SETD2, SMC1A and ZMYM3. ...Collectively, our results help to define the landscape of mutations in epigenetic regulatory genes in paediatric cancer …
最常见的突变基因是H3F3A、PHF 6、ATRX、KDM6A、SMARCA 4、ASXL2、CREBBP、EZH2、MLL2、USP 7、ASXL1、NSD 2、SET D2、SMC1A和ZMYM 3。...总的来说，我们的研究结果有助于确定儿科癌症中表观遗传调控基因突变的情况。
The most frequently mutated genes are H3F3A, PHF6, ATRX, KDM6A, SMARCA4, ASXL2, CREBBP, EZH2, MLL2, USP7, ASXL1, NSD2, SETD2, SMC1A a …
Molecular Profiling Defines Distinct Prognostic Subgroups in Childhood AML: A Report From the French ELAM02 Study Group.
分子谱确定儿童AML的不同预后亚组：来自法国ELAM 02研究组的报告 HemasphereSCI升级版 医学2区IF 9.1
Marceau-Renaut A, Duployez N, Ducourneau B, Labopin M, Petit A, Rousseau A, Geffroy S, Bucci M, Cuccuini W, Fenneteau O, Ruminy P, Nelken B, Ducassou S, Gandemer V, Leblanc T, Michel G, Bertrand Y, Baruchel A, Leverger G, Preudhomme C, Lapillonne H. Marceau-Renaut A, et al. Hemasphere. 2018 Feb 21;2(1):e31. doi: 10.1097/HS9.0000000000000031. eCollection 2018 Jan-Feb. Hemasphere. 2018. PMID: 31723759 Free PMC article.
The most common class of mutations involved genes that control kinase signaling (61%) followed by transcription factors (16%), tumor suppressors (14%), chromatin modifiers (9%), DNA methylation controllers (8%), cohesin genes (5%), and spliceosome (3%). ...Overall, CBF rea …
最常见的突变类型涉及控制激酶信号传导的基因（61%），其次是转录因子（16%），肿瘤抑制因子（14%），染色质修饰因子（9%），DNA甲基化控制因子（8%），粘附素基因（5%）和剪接体（3%）。...总的来说，CBF真…
The most common class of mutations involved genes that control kinase signaling (61%) followed by transcription factors (16%), tumor …
Identification of temozolomide resistance factors in glioblastoma via integrative miRNA/mRNA regulatory network analysis.
通过整合miRNA/mRNA调控网络分析鉴定胶质母细胞瘤中的替莫唑胺耐药因子 Scientific ReportsSCI升级版 综合性期刊2区SCI基础版 综合性期刊3区IF 4.6
Hiddingh L, Raktoe RS, Jeuken J, Hulleman E, Noske DP, Kaspers GJ, Vandertop WP, Wesseling P, Wurdinger T. Hiddingh L, et al. Sci Rep. 2014 Jun 11;4:5260. doi: 10.1038/srep05260. Sci Rep. 2014. PMID: 24919120 Free PMC article.
Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 expression in three TMZ-resistant subclones significantly enhanced TMZ-induced cell kill in two of these cell lines. ...
PHF 6表达的分析显示，与正常组织相比，胶质母细胞瘤中PHF 6表达显著上调。干扰PHF 6的表达在三个TMZ耐药的亚克隆显着增强TMZ诱导的细胞杀死这些细胞系中的两个。...
Analysis of PHF6 expression showed significant upregulation in glioblastoma as compared to normal tissue. Interference with PHF6 …
Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL.
儿童B-ALL中种族群体内和种族群体间基因表达变异模式的分析 Cancer InformaticsIF 2.0
癌症信息IF 2.0
Hicks C, Miele L, Koganti T, Young-Gaylor L, Rogers D, Vijayakumar V, Megason G. Hicks C, et al. Cancer Inform. 2013 Aug 27;12:155-73. doi: 10.4137/CIN.S11831. eCollection 2013. Cancer Inform. 2013. PMID: 24023509 Free PMC article.

B-Precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Although 80% of B-ALL patients are able to be cured, significant challenges persist. ...We identified 300 highly significantly (P < 0.001) differentially expressed genes between the fo
B-前体急性淋巴细胞白血病（B-ALL）是最常见的儿童癌症。尽管80%的B-ALL患者能够治愈，但仍然存在重大挑战。...我们发现了300个高度显著（P < 0.001）的差异表达基因。

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B-Precursor acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Although 80% of B-ALL patients are able to be c …
A novel strategy based on histological protein profiling in-silico for identifying potential biomarkers in urinary bladder cancer.
一种新的策略，基于组织学蛋白质分析在电脑识别潜在的生物标志物在膀胱癌。 Bju InternationalSCI升级版 医学2区SCI基础版 医学2区IF 4.5
Segersten MU, Edlund EK, Micke P, de la Torre M, Hamberg H, Edvinsson AE, Andersson SE, Malmström PU, Wester HK. Segersten MU, et al. BJU Int. 2009 Dec;104(11):1780-5. doi: 10.1111/j.1464-410X.2009.08674.x. Epub 2009 Jun 12. BJU Int. 2009. PMID: 19522865

None or limited previous characterization in bladder cancer, as well as a supportive Western blot, were also required. ...Expression patterns for seven proteins were significantly altered (P < 0.05) with higher stage and/or grade. Three of those (CN130, DSG3, PHF6
也不需要或需要有限的膀胱癌先前表征以及支持性蛋白质印迹。... 7种蛋白质的表达模式随肿瘤分期和/或分级的增高而显著改变（P < 0.05）。其中三种（CN 130、DSG 3、PHF 6

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None or limited previous characterization in bladder cancer, as well as a supportive Western blot, were also required. ...Expression …
T-cell acute lymphoblastic leukemia in association with Borjeson-Forssman-Lehmann syndrome due to a mutation in PHF6.
PHF 6突变导致的Borjeson-Forssman-Lehmann综合征相关的T细胞急性淋巴细胞白血病 Pediatric Blood & CancerSCI升级版 医学3区SCI基础版 医学3区IF 3.2
Chao MM, Todd MA, Kontny U, Neas K, Sullivan MJ, Hunter AG, Picketts DJ, Kratz CP. Chao MM, et al. Pediatr Blood Cancer. 2010 Oct;55(4):722-4. doi: 10.1002/pbc.22574. Pediatr Blood Cancer. 2010. PMID: 20806366 Free PMC article.
The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localization sequences. Previously, overexpression of Phf6 was observed in murine T-cell lymphomas. Our observation indicates that BFLS may repr …
PHF 6基因位于X染色体上，编码一个具有两个PHD型锌指结构域和四个核定位序列的蛋白质。以前，在鼠T细胞淋巴瘤中观察到Phf 6的过表达。我们的观察表明，BFLS可能代表…
The PHF6 gene is located on the X chromosome and encodes a protein with two PHD-type zinc finger domains and four nuclear localizatio …
Radiation leukemia virus common integration at the Kis2 locus: simultaneous overexpression of a novel noncoding RNA and of the proximal Phf6 gene.
放射性白血病病毒在Kis 2位点的共同整合：一种新型非编码RNA和近端Phf 6基因的同时过表达 Journal of Virology医学TOPSCI升级版 医学2区SCI基础版 医学2区IF 5.4
Landais S, Quantin R, Rassart E. Landais S, et al. J Virol. 2005 Sep;79(17):11443-56. doi: 10.1128/JVI.79.17.11443-11456.2005. J Virol. 2005. PMID: 16103195 Free PMC article.
Retroviral tagging has been used extensively and successfully to identify genes implicated in cancer pathways. In order to find oncogenes implicated in T-cell leukemia, we used the highly leukemogenic radiation leukemia retrovirus VL3 (RadLV/VL3). ...In this article, we re …
逆转录病毒标签已被广泛和成功地用于识别与癌症途径有关的基因。为了寻找与T细胞白血病有关的癌基因，我们使用了高度致白血病的放射性白血病逆转录病毒VL 3（RadLV/VL 3）。...在这篇文章中，我们重新…
Retroviral tagging has been used extensively and successfully to identify genes implicated in cancer pathways. In order to find oncog …
Rapid Identification of Key Copy Number Alterations in B- and T-Cell Acute Lymphoblastic Leukemia by Digital Multiplex Ligation-Dependent Probe Amplification.
通过数字多重连接依赖探针扩增快速鉴定B细胞和T细胞急性淋巴细胞白血病中的关键拷贝数改变。 Frontiers in OncologySCI升级版 医学3区SCI基础版 医学2区IF 4.7
Thakral D, Kaur G, Gupta R, Benard-Slagter A, Savola S, Kumar I, Anand R, Rani L, Verma P, Joshi S, Kumar L, Sharma A, Bakhshi S, Seth R, Singh V. Thakral D, et al. Front Oncol. 2019 Sep 13;9:871. doi: 10.3389/fonc.2019.00871. eCollection 2019. Front Oncol. 2019. PMID: 31572674 Free PMC article.
Heterozygous and homozygous gene deletions, and duplications were observed in genes involved in cell cycle control, tumor suppression, lineage differentiation, lymphoid signaling, and transcriptional regulators with implications in treatment response and survival outcome. …
在涉及细胞周期控制、肿瘤抑制、谱系分化、淋巴信号传导和转录调节因子的基因中观察到杂合和纯合基因缺失和重复，并影响治疗反应和生存结局。…
Heterozygous and homozygous gene deletions, and duplications were observed in genes involved in cell cycle control, tumor suppression …
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