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表 1 二元 logistic 回归分析中使用的变量基本信息
Table 1 Variables used in binary logistic regression analysis (basic information).

变量类别
Variable category

特定变量
Specific variables

患者人口统计数据
Patient demographics

年龄(≤64 岁和 ≥65 岁)、性别(男性和女性)、种族(白人、黑人、西班牙裔、亚洲或太平洋岛民、美洲原住民和其他)
Age (≤ 64 and ≥65), Gender (Male and Female), Ethnicity (White, Black, Hispanic, Asian or Pacific Islander, Native American, and Other)

医院特色
Hospital features

入院类型(非选修、选修)、医院床位大小(小型、中型、大型)、医院教学状况(非教学、教学)、医院位置(农村、城市)、保险类型(医疗保险、医疗补助、私人保险、自费、免费、其他)、医院位置(东北部、中西部或中北部、南部、西部)
Admission Type (Non-Elective, Elective), Hospital Bed Size (Small, Medium, Large), Hospital Teaching Status (Non-Teaching, Teaching), Hospital Location (Rural, Urban), Insurance Type (Medicare, Medicaid, Private Insurance, Self-pay, Free, Other), Hospital Location (Northeast, Midwest or North-Central, Southern, Western)

合并症
Complications

艾滋病、酗酒、缺乏性贫血、类风湿病、慢性失血性贫血、充血性心力衰竭、慢性肺病、凝血障碍、抑郁症、糖尿病(无并发症)、糖尿病(有慢性并发症)、药物滥用、高血压、甲状腺功能减退症、肝病、淋巴瘤、液体和电解质紊乱、转移性癌症、神经系统疾病、肥胖、瘫痪、外周血管疾病、精神病、肺循环障碍、肾功能衰竭、实体瘤无转移、消化性溃疡病、瓣膜病和体重减轻
AIDS, alcoholism, deficiency anemia, rheumatoid disease, chronic hemorrhagic anemia, congestive heart failure, chronic lung disease, coagulopathy, depression, diabetes mellitus (without complications), diabetes mellitus (with chronic complications), substance abuse, hypertension, hypothyroidism, liver disease, lymphoma, fluid and electrolyte disorders, metastatic cancer, neurological disease, obesity, paralysis, peripheral vascular disease, psychiatric disorders, pulmonary circulatory disorders, renal failure, solid tumors without metastases, peptic ulcer disease, Valvular disease and weight loss

检验信息
Inspection information

检查信息
Check the information

艾滋病: 获得性免疫缺陷综合症
AIDS: Acquired Immunodeficiency Syndrome

表 2 全膝关节置换术后患者特征和结局 (2010-2019)
Table 2 Patient characteristics and outcomes after total knee arthroplasty (2010-2019).

单因素分析
Univariate analysis

特性
characteristic

输液
transfusion

无输血
No blood transfusions

P

总计 (n=计数)
Total (n=count)

82,52

1,167,1

总发病率 (%)
Total Incidence (%)

5.60

年龄(中位数/平均值,岁)
Age (median/mean, years).

37.520.0, 62.3)

44.4 23.3)

0.772

年龄组别 (%)
Age Group (%)

18-44

11.17

11.45

<0.001

45-64

33.41

50.74

65-74

36.98

37.68

≥75

32.79

29.53

性别 (%)
Gender (%)


male

35

40

0.154

女性
female

65

54.2

种族 (%)
Ethnicity (%)


white

27.42

81.54

<0.001


black

61.29

9.86

西班牙的
Spanish

16.48

6.62

亚洲或太平洋岛民
Asian or Pacific Islander

10.58

10.31

印第安人
Native American

2.44

0.47

其他
other

9.37

0.20

合并症数量 (%)
Number of comorbidities (%)

0

5.30

6.35

<0.001

1

8.01

3.14

2

1.86

14.79

3

65.84

81.72

LOS(中位数,d)
LOS (median, d)

13 (3-4)

32 (2-3)

<0.001

TOTCHG(中位数、$)
TOTCHG (median, $).

5,62

(4,49-8,92)

5,045

(32,57-71,59)

<0.001

保险类型 (%)
Type of Insurance (%)

医疗
medical

61.29

50.43

<0.001

医疗 补助
Medicaid

13.52

13.86

私人保险
Private insurance

18.12

16.86

自费
At your own expense

0.53

10.47

免费
gratis

0.58

0.76

其他
other

2.17

1.32

医院床位大小 (%)
Hospital bed size (%)


small

21.01

20.98

<0.001

中等
medium

20.32

37.40


big

41.60

40.51

选择性录取 (%)
Selective Admission (%)

90.55

82.88

<0.001

医院类型(教学 %)
Hospital Type (Teaching %)

41.33

24.61

<0.001

继续
Go on

特性
characteristic

输液
transfusion

无输血
No blood transfusions

P

医院位置(城市,%)
Hospital location (city, %)

80.46

79.64

<0.001

医院区域 (%)
Hospital Area (%)

东北
northeast

21.42

11.61

<0.001

中西部或中北部
Midwest or North Midwest

28.00

20.68


south

41.81

25.44

西
west

10.76

18.47

死亡 (%)
Deaths (%)

0.21

1.04

<0.001

LOS逗留时间,TOTCHE:总费用
LOS: LENGTH OF STAY, TOTCHE: TOTAL COST

表 3 全膝关节置换术后输血相关危险因素
Table 3 Risk factors associated with blood transfusion after total knee arthroplasty

多因素分析
Multivariate analysis

变量
variable

多元 Logistic 回归
Multivariate logistic regression

95% CI

P

年龄 ≥65 岁
Age ≥65 years

2.21

1.08-1.65

<0.001


male

0.8

0.22 2.91

0.744

比赛
race

白色(0)
White (0).

编号(1)
Number (1).

——

——

黑色(1)
Black (1).

1.37

1.46-1.87

<0.001

西班牙裔(1)
Hispanic (1).

1.22

1.32-1.40

<0.001

亚洲或太平洋岛民(1)
Asian or Pacific Islander (1).

1.27

1.20-1.39

<0.001

美洲原住民(1)
Native Americans (1).

0.69

0.49-1.90

0.95

其他
other

1.51

1.17-1.89

<0.001

合并症数量
Number of comorbidities

1

裁判
umpire

——

——

2

1.53

0.67-1.67

0.901

≥3

0.99

0.94-1.05

0.808

保险类型
Type of insurance

医疗
medical

裁判
umpire

——

——

医疗 补助
Medicaid

0.73

0.81-0.99

<0.001

私人保险
Private insurance

0.64

0.63-0.82

<0.001

自费
At your own expense

0.87

0.79-0.91

0.021

免费
gratis

1.02

0.66-1.56

0.509

其他
other

0.64

0.81-0.89

<0.001

医院床位大小
The size of the hospital bed


small

裁判
umpire

——

——

中等
medium

1.19

1.05-1.21

<0.001


big

1.06

1.14-1.39

<0.001

选修入学
Elective Admission

0.82

0.60-0.84

<0.001

教学医院
teaching hospital

0.08

0.76-0.99

<0.001

城市医院
City Hospital

0.98

0.56-0.80

<0.001

医院所在地区
The area where the hospital is located

东北
northeast

裁判
umpire

——

——

中西部或中北部
Midwest or North Midwest

0.61

0.40-0.56

<0.001


south

0.24

0.71-0.80

<0.001

西
west

0.50

0.58-0.71

<0.001

艾滋病:获得性免疫缺陷综合征,OR:比值比,CI:置信区间
AIDS: Acquired Immunodeficiency Syndrome, OR: odds ratio, CI: confidence interval

4 输血与术前合并症的关系
Table 4: Relationship between blood transfusion and preoperative comorbidities

合并症单因素+多因素
Comorbidities (univariate + multivariate).

合并症
Complications

单变量分析
Univariate analysis

多元 Logistic 回归
Multivariate logistic regression

无输血
No blood transfusions

输液
transfusion

P

95% CI

P

Preoperative comorbidities

获得性免疫缺陷综合症
Acquired immunodeficiency syndrome

855 (0.1%)

140 (0.1%)

0.011

0.2

0.3-0.8

0.024

酗酒
binge drinking

10,98 (0.8%)

99 (1.0%)

<0.001

1.1

0.8-1.3

0.108

缺乏性贫血
Deficiency anemia

67,80 (5.6%)

1,68 (12.1%)

<0.001

3.1

2.2-3.8

<0.001

类风湿性关节炎/胶原血管疾病
Rheumatoid arthritis/collagen vascular disease

45,99 (3.4%)

461 (5.2%)

<0.001

1.5

1.3-1.3

<0.001

慢性失血性贫血
Chronic hemorrhagic anemia

926 (0.7%)

294 (3.5%)

<0.001

3.0

3.0-3.8

<0.001

充血性心力衰竭
Congestive heart failure

297,7 (2.1%)

411 (5.3%)

<0.001

1.6

1.4-1.8

<0.001

慢性肺病
Chronic lung disease

178 (10.8%)

19 (11.2%)

<0.001

1.2

1.2-1.6

0.035

凝血功能障碍
Coagulopathy

18,87 (1.1%)

457 (4.3%)

<0.001

2,5

2.1-2.8

<0.001

抑郁症
depression

1610 (11.7%)

120 (11.8%)

<0.001

1.1

1.2-1.3

0.004

糖尿病,无并发症
Diabetes mellitus, without complications

2114 (11.1%)

146 (20.2%)

<0.001

1.2

1.9-1.9

<0.001

滥用药物
drug abuse

696 (0.2%)

55 (0.1%)

0.006

1.3

0.4-1.2

0.546

高血压
hypertension

7897 (67.1%)

602 (7.4%)

<0.001

1.4

1.1-1.6

<0.001

甲状腺功能减退症
Hypothyroidism

1939 (16.03%)

130 (18.3%)

<0.001

1.1

1.8-1.9

<0.001

肝病
hepatopathy

155 (1.6%)

18 (1.1%)

<0.001

0.1

0.6-0.7

0.003

淋巴瘤
lymphoma

267 (0.39%)

33 (0.5%)

<0.001

1.1

1.5-1.3

<0.001

体液和电解质紊乱
Fluid and electrolyte imbalances

764 (6.3%)

132 (15.6%)

<0.001

2.0

2.1-2.0

<0.001

转移性癌症
Metastatic cancer

775 (0.06%)

155 (0.19%)

<0.001

2.1

1.5-2.3

<0.001

其他神经系统疾病
Other neurological disorders

282 (2.3%)

46 (5.6%)

<0.001

1.8

1.2-1.9

<0.001

肥胖
corpulent

362 (2.4%)

183 (2.2%)

<0.001

0.7

0.60-0.60

<0.001

瘫痪
paralysis

202 (0.8%)

36 (0.3%)

<0.001

1.6

1.10-1.80

<0.001

外周血管疾病
Peripheral vascular disease

237 (2.1%)

21 (3.9%)

<0.001

1.9

1.30-1.90

<0.001

精神病
mentally ill

257 (2.2%)

29 (2.4%)

<0.001

1.20

1.10-1.40

<0.001

肺循环障碍
Pulmonary circulatory disorders

938 (0.6%)

175 (2.3%)

<0.001

1.40

1.10-1.50

<0.001

肾功能衰竭
Kidney failure

558 (5.2%)

76 (7.1%)

<0.001

1.30

1.30-1.40

<0.001

无转移的实体瘤
Solid tumors without metastases

537 (0.6%)

51 (0.4%)

<0.001

1.10

1.00-1.20

0.002

瓣膜病
Valvular disease

370 (3.8%)

42 (5.3%)

<0.001

1.40

1.2-1.50

<0.001

减肥
weight loss

28 (0.2%)

674 (0.2%)

<0.001

2.410

2.30-2.60

<0.001

OR:比值比,CI:置信区间
OR: odds ratio, CI: confidence interval

5 输血与术后并发症的关系
Table 5 Relationship between blood transfusion and postoperative complications

并发症单因素+多因素
Complications (univariate + multifactorial).

并发症s
Complications

单变量分析
Univariate analysis

多元 Logistic 回归
Multivariate logistic regression

无输血
No blood transfusions

输液
transfusion

P

95% CI

P

躯体并发症
Medical complications

败血症
septicemia

118 (0.19%)

48 (0.5%)

<0.001

3.7

2.8-3.8

<0.001

急性心肌梗死
Acute myocardial infarction

332 (0.1%)

167 (1.9%)

<0.001

3.9

3.3-3.9

<0.001

深静脉血栓形成
Deep vein thrombosis

33 (0.6%)

75 (0.9%)

<0.001

2.1

2.08-3.6

<0.001

消化道出血
Gastrointestinal bleeding

51 (0.4%)

24 (0.3%)

<0.001

5.8

5.1-6.7

<0.001

心搏骤停
cardiac arrest

478(0.4%)

14 (0.1%)

<0.001

1.7

1.2-2.1

<0.001

休克
shock

14 (0.1%)

85(0.10%)

<0.001

4.0

3.1-5.6

<0.001

肺炎
pneumonia

218 (0.5%)

91 (1.4%)

<0.001

3.3

3.0-3.6

<0.001

中风
stroke

524 (0.4%)

74 (0.9%)

<0.001

1.9

1.4-2.1

<0.001

手术并发症
Complications of surgery

假体周围关节感染
Periprosthetic joint infection

81 (0.7%)

30 (0.3%)

<0.001

3.63

3.15-4.18

<0.001

假体关节脱位
Prosthetic joint dislocation

126 (0.01%)

40 (0.05%)

<0.001

3.1

2.5-5.5

<0.001

溶血
hemolysis

5 (0.00%)

7 (0.01%)

<0.001

1.03

1.03-5.1

<0.001

下肢神经损伤
Nerve damage in the lower extremities

17 (0.01%)

3 (0.04%)

0.01

2.8

1.8-3.6

<0.001

出血
haemorrhage

205 (0.17%)

11 (1.37%)

<0.001

7.1

6.9-7.7

<0.001

OROdds 比率,CI:Confidence interval
OR:Odds ratio, CI:Confidence interval

检查、检验单因素+多因素
Inspect and inspect single factor + multiple factor

检验信息两组比较和危险因素分析
Comparison of test information between two groups and analysis of risk factors

检查信息两组间比较及危险因素分析
Comparison of examination information between the two groups and analysis of risk factors

6大表格+1个流程图+1个柱状图
6 large tables + 1 flowchart + 1 bar chart

图片分辨率 (尺寸)300dpi(PS调整)或更高分辨率 RGB颜色模式
Image resolution (size): 300dpi (PS adjustment) or higher resolution RGB color mode

PS调整图片分辨率
P.S. Adjust the picture resolution

图片表格 12以上,不超过18 Arial字体
Image table 12 or more, no more than 18 Arial fonts

文章正文11号字号 Times New Roman字体 1.5行间距
Article body 11 font size Times New Roman font 1.5 line spacing

表格正文11号字号 Times New Roman字体 1.0行间距
Table body 11 font size Times New Roman font 1.0 line spacing

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Vector files

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Bitmap images