这是用户在 2024-3-13 23:53 为 https://link.springer.com/article/10.1007/s00266-020-01684-4 保存的双语快照页面，由 沉浸式翻译 提供双语支持。了解如何保存？
Skip to main content

Advertisement

SpringerLink
Log in

Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report

Aesthetic Plastic Surgery Aims and scope Submit manuscript  提交稿件

Abstract 抽象

Objective 目的

Botulinum toxin injection, micro-needling injection, and filler injection are the most widely used non-surgical facial cosmetic treatments. Hypersensitivity reactions associated with injections have not received sufficient attention due to their low incidence rates. The authors tried to summarize the characteristics of the hypersensitivity caused by cosmetic injections and helped to improve the diagnosis and treatment.
肉毒杆菌毒素注射、微针注射和填充剂注射是应用最广泛的非手术面部美容治疗。由于发生率低，与注射相关的超敏反应没有得到足够的重视。作者试图总结美容注射引起的超敏反应的特征，并帮助改善诊断和治疗。

Methods 方法

A comprehensive search of the PubMed database to September 2019 was performed. Articles were screened using predetermined inclusion and exclusion criteria. Data collected included patient characteristics, injection information (injected material, trade name, location of injection, symptoms of allergy, time of onset), diagnostic examination, treatment, and prognosis.
对截至 2019 年 9 月的 PubMed 数据库进行了全面检索。使用预先确定的纳入和排除标准对文章进行筛选。收集的数据包括患者特征、注射信息（注射材料、商品名、注射位置、过敏症状、发病时间）、诊断检查、治疗和预后。

Results 结果

A total of 14 articles (57 patients) were included. There were 3 patients receiving botulinum toxin injection, 3 patients receiving micro-needling injection, and 46 patients receiving hyaluronic acid injection. Five patients were injected with collagen, polyacrylamide, paraffin, alkyl-imide or hyaluronidase, separately. The symptoms were redness, swelling, itching or induration at the injection site. The diagnosis and treatment methods vary greatly depending on the injection fillers. Removing the injected filler is the primary treatment.
共纳入14篇文章（57名患者）。肉毒杆菌毒素注射3例，微针注射3例，透明质酸注射46例。5例患者分别注射胶原蛋白、聚丙烯酰胺、石蜡、烷基酰亚胺或透明质酸酶。症状是注射部位发红、肿胀、瘙痒或硬结。诊断和治疗方法因注射填充剂而异。去除注射的填充剂是主要治疗方法。

Conclusion 结论

Although hypersensitivity reaction is a relatively uncommon adverse event, more practice guidelines and research on diagnosis and treatment are demanded to help improve the outcomes.
尽管超敏反应是一种相对罕见的不良事件，但需要更多的实践指南和诊断和治疗研究来帮助改善结局。

Level of Evidence III 证据等级 III

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the table of contents or the online instructions to authors www.springer.com/00266.
该期刊要求作者为每篇文章分配一定程度的证据。有关这些循证医学评级的完整说明，请参阅目录或作者在线说明 www.springer.com/00266。

This is a preview of subscription content, log in via an institution to check access.
这是订阅内容的预览，通过机构登录以检查访问权限。

Access this article 访问此文章

Log in via an institution
通过机构登录

Price includes VAT (China (P.R.))
价格包括增值税 （中国 （P.R.））

Instant access to the full article PDF.
即时访问全文 PDF。

Rent this article via DeepDyve
通过 DeepDyve 租借这篇文章

Institutional subscriptions
机构认购

Fig. 1 图1
Fig. 2 图2
Fig. 3 图3
Fig. 4 图4
Fig. 5 图5
Fig. 6 图6
Fig. 7 图7
Fig. 8 图8

Similar content being viewed by others
其他人正在查看类似内容

References 引用

  1. US Food and Drug Administration. Information for healthcare professionals: onabotulinumtoxinA (marketed as Botox/Botox Cosmetic), abobotulinumtoxinA (marketed as Dysport) and rimabotulinumtoxinB (marketed as Myobloc). https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174949.htm
    美国食品和药物管理局。医疗保健专业人员信息：肉毒杆菌毒素A（作为肉毒杆菌毒素/肉毒杆菌毒素化妆品销售）、肉毒杆菌毒素A（作为Dysport销售）和rimabotulinumtoxinB（作为Myobloc销售）。https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/ucm174949.htm

  2. Massone C, Horn M, Kerl H et al (2009) Foreign body granuloma due to matridex injection for cosmetic purposes[J]. Am J Dermatopathol 31(2):197–199
    Massone C， Horn M， Kerl H et al （2009） 用于美容目的的matridex注射引起的异物肉芽肿[J].美国皮肤病理学杂志 31（2）：197–199

    Article 品  Google Scholar Google 学术搜索 

  3. Grippaudo FR, Mattei M (2010) High-frequency sonography of temporary and permanent dermal filers. Skin Res Technol 16:265–269
    Grippaudo FR， Mattei M （2010） 临时和永久真皮锉刀的高频超声检查。皮肤研究技术 16：265-269

    PubMed PubMed的  Google Scholar Google 学术搜索 

  4. Christensen L (2007) Normal and pathologic tissue reactions to soft tissue gel filers. Dermatol Surg 33(Suppl 2):S168–S175
    Christensen L （2007） 对软组织凝胶锉刀的正常和病理组织反应。皮肤外科 33（增刊 2）：S168–S175

    CAS  PubMed PubMed的  Google Scholar Google 学术搜索 

  5. Kobayashi K, Kaneda K, Kasama T (2001) Immunopathogenesis of delayed-type hypersensitivity[J]. Microsc Res Tech 53:241–245
    Kobayashi K， Kaneda K， Kasama T （2001） 迟发型超敏反应的免疫发病机制[J].Microsc Res Tech 53：241-245

    Article 品  CAS  Google Scholar Google 学术搜索 

  6. Pichler WJ (2003) Delayed drug hypersensitivity reactions[J]. Ann Intern Med 139:683–693
    Pichler WJ （2003） 迟发性药物超敏反应[J].Ann Intern Med 139：683-693

    Article 品  CAS  Google Scholar Google 学术搜索 

  7. Jelinek C. Appendix E (1990) Diagnostic procedures-delayed hypersensitivity skin testing.In: Allergy/Immunology specialist course manual, 5th edn. US Army, E-1–11
    Jelinek C. Appendix E （1990） 诊断程序-延迟超敏反应皮肤测试。在：过敏/免疫学专家课程手册，第 5 版。美国陆军，E-1-11

  8. Roitt IM (1998) Essential immunology. 9th edn. Oxford, UK: Blackwell Scientific, Chapters 22–23
    Roitt IM （1998） 基本免疫学。第 9 版。英国牛津：布莱克韦尔科学，第 22-23 章

  9. Careta MF, Delgado L, Patriota R (2015) Report of allergic reaction after application of botulinum toxin[J]. Aesthet Surg J 35(5):NP102–NP105
    Careta MF， Delgado L， Patriota R （2015） 应用肉毒杆菌毒素后过敏反应报告[J].美术外科杂志 35（5）：NP102–NP105

    Article 品  Google Scholar Google 学术搜索 

  10. Moon IJ, Chang SE, Kim SD (2017) First case of anaphylaxis after botulinum toxin type A injection[J]. Clin Exp Dermatol 42(7):760–762
    Moon IJ， Chang SE， Kim SD （2017） A型肉毒杆菌毒素注射后全身性过敏反应首例[J].临床体验皮肤 42（7）：760–762

    Article 品  CAS  Google Scholar Google 学术搜索 

  11. Rosenfield LK, Kardassakis DG, Tsia KA et al (2014) The first case report of a systemic allergy to onabotulinumtoxinA (Botox) in a healthy patient[J]. Aesthet Surg J 34(5):766–768
    Rosenfield LK， Kardassakis DG， Tsia KA et al （2014） 健康患者全身性肉毒杆菌毒素A（肉毒杆菌毒素）全身过敏的首例病例报告[J].美术外科杂志 34（5）：766–768

    Article 品  Google Scholar Google 学术搜索 

  12. Kamin W, Staubach P, Klär-Hlawatsch B (2006) Anaphylaxis after vaccination due to hypersensitivity to gelatin[J]. Klin Padiatr 218(2):92–94
    Kamin W， Staubach P， Klär-Hlawatsch B （2006） 疫苗接种后明胶过敏引起的过敏反应[J].克林儿科 218（2）：92-94

    Article 品  CAS  Google Scholar Google 学术搜索 

  13. Soltani-Arabshahi R, Wong JW, Duffy KL et al (2014) Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation[J]. JAMA Dermatol 150(1):68–72
    Soltani-Arabshahi R， Wong JW， Duffy KL et al （2014） 微针治疗嫩肤面部过敏肉芽肿反应及全身超敏反应[J].美国医学会皮肤杂志 150（1）：68–72

    Article 品  Google Scholar Google 学术搜索 

  14. Cassuto D, Sundaram H (2013) A problem-oriented approach to nodular complications from hyaluronic acid and calcium hydroxylapatite fillers: classification and recommendations for treatment[J]. Plast Reconstr Surg 132(4 Suppl 2):48S–58S
    Cassuto D， Sundaram H （2013） 透明质酸和羟基磷灰石钙填充剂结节性并发症的分类和治疗建议[J].塑料研究外科 132（4 增刊 2）：48S–58S

    Article  CAS  Google Scholar 

  15. Jeong ML, Yu JK (2015) Foreign body granulomas after the use of dermal fillers: pathophysiology, clinical appearance, histologic features, and treatment[J]. Arch Plast Surg 42(2):232–239

    Article  Google Scholar 

  16. Lowe NJ, Maxwell CA, Patnaik R (2005) Adverse reactions to dermal fillers: review[J]. Dermatol Surg 31:1616–1625

    CAS  PubMed  Google Scholar 

  17. Lemperle G, Gauthier-Hazan N, Wolters M et al (2009) Foreign body granulomas after all injectable dermal fillers: part 1 Possible causes[J]. Plast Reconstr Surg 123(6):1842–1863

    Article  CAS  Google Scholar 

  18. Bitterman-Deutsch O, Kogan L, Nasser F (2015) Delayed immune mediated adverse effects to hyaluronic acid fillers: report of five cases and review of the literature[J]. Dermatol Rep 7(1):5851

    Article  Google Scholar 

  19. Alijotas-Reig J, Fernández-Figueras MT, Puig L (2013) Late-onset inflammatory adverse reactions related to soft tissue filler injections[J]. Clin Rev Allergy Immunol 45(1):97–108

    Article  CAS  Google Scholar 

  20. Rongioletti F (2008) Granulomatous reactions from aesthetic dermal micro-implants[J]. Ann Dermatol Venereol 135(1 Pt 2):1S59–65

    CAS  PubMed  Google Scholar 

  21. Mohammed GT, Koenraad DB, Wolfgang PD (2019) Delayed hypersensitivity reaction to hyaluronic acid dermal filler following influenza-like illness[J]. Clin Cosmet Investig Dermatol 12:277–283

    Article  Google Scholar 

  22. Shahrabi FS, Sexton J, Stone JD et al (2012) Lip nodules caused by hyaluronic acid filler injection: report of three cases[J]. Head Neck Pathol 6(1):16–20

    Article  Google Scholar 

  23. Artzi O, Loizides C, Verner I (2016) Resistant and recurrent late reaction to hyaluronic acid-based gel[J]. Dermatol Surg 42(1):31–37

    Article  CAS  Google Scholar 

  24. Kim MS, Youn S, Na CH et al (2015) Allergic reaction to hyaluronidase use after hyaluronic acid filler injection[J]. J Cosmet Laser Ther 17(5):283–285

    Article  Google Scholar 

  25. Alijotas-Reig J, Fernández-Figueras MT, Puig L (2013) Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers[J]. Semin Arthritis Rheum 43(2):241–258

    Article  CAS  Google Scholar 

  26. Lee SK, Kim SM, Cho SH et al (2015) Adverse reactions to injectable soft tissue fillers: memorable cases and their clinico-pathological overview[J]. J Cosmet Laser Ther 17(2):102–108

    Article  Google Scholar 

  27. Chang C, Lee SB (2015) Unusual long-term complication of polyalkylimide hydrogel manifesting as nasal septal abscess[J]. J Craniofac Surg 26(3):e197–e199

    Article  Google Scholar 

  28. Bhojani-Lynch T (2017) Late-onset inflammatory response to hyaluronic acid dermal fillers[J]. Plast Reconstr Surg Glob Open 5(12):e1532

    Article  Google Scholar 

  29. Kanoh S, Rubin BK (2010) Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev 23:590–615

    Article  CAS  Google Scholar 

  30. Chang JR, Baharestani S, Salek SS et al (2017) Delayed superficial migration of retained hyaluronic acid years following periocular injection[J]. Ophthalmic Plast Reconstr Surg 33(3S Suppl 1):S116–S118

    Article  Google Scholar 

  31. Landau M (2015) Hyaluronidase caveats in treating filler complications[J]. Dermatol Surg 41(Suppl 1):S347–S353

    Article  Google Scholar 

  32. Sundaram H, Voigts B, Beer K, Meland M (2010) Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue filers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg 36(Suppl 3):1859–1865

    Article  CAS  Google Scholar 

  33. Glogau RG, Kane MA (2008) Effect of injection techniques on the rate of local adverse events in patients implanted with nonanimal hyaluronic acid gel dermal filers. Dermatol Surg 34(Suppl 1):S105–S109

    CAS  PubMed  Google Scholar 

  34. Sundaram H, Monheit GD, Goldman MP (2012) Clinical experiences with hyaluronic acid filers: roundtable discussion. J Drugs Dermatol 11:15–27

    Google Scholar 

  35. Auler ME, Morreira D, Rodrigues FF et al (2010) Biofim formation on intrauterine devices in patients with recurrent vulvovaginal candidiasis. Med Mycol 48:211–216

    Article  CAS  Google Scholar 

  36. Lewis K (2001) Riddle of biofim resistance. Antimicrob Ag Chemother 45:999–1007

    Article  CAS  Google Scholar 

  37. Rohrich RJ, Monheit G, Nguyen AT, Brown SA, Fagien S (2010) Soft-tissue filer complications: the important role of biofims. Plast Reconstr Surg 125:1250–1256

    Article  CAS  Google Scholar 

  38. Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH (2009) Detection of bacteria by florescence in situ hybridization in culture-negative soft tissue filer lesions. Dermatol Surg 35(Suppl 2):1620–1624

    Article  CAS  Google Scholar 

  39. Voigts R, DeVore DP, Neuman P, Grazer J (2010) Dispersion of calcium hydroxylapatite accumulations in the skin: animal studies and clinical practices. Dermatol Surg 36(Suppl):798–803

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Plastic Surgery of Peking Union Medical College Hospital Of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

    Chenyu Wang, Hairui Li, Zhijin Li & Xiaojun Wang

  2. Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, Oxford, UK

    Tianyu Sun

Authors
  1. Chenyu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tianyu Sun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Hairui Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhijin Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xiaojun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Xiaojun Wang.

Ethics declarations

Conflict of interest

We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work. There is no professional or other personal interest of any nature or kind in any product, service, and/or company that could be construed as influencing the position presented in the manuscript.

Statement of Human and Animal Rights

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed Consent

The patient had signed the informed consent.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wang, C., Sun, T., Li, H. et al. Hypersensitivity Caused by Cosmetic Injection: Systematic Review and Case Report. Aesth Plast Surg 45, 263–272 (2021). https://doi.org/10.1007/s00266-020-01684-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00266-020-01684-4

Keywords